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Fluorescein-5-isothiocyanate (FITC)

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Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.

Also Known As:

FITC; Fluorescein 5 isothiocyanate; 5-Isothiocyanatofluorescein; Fluorescein (5 or 6)-Isothiocyanate; Fluorescein-5-isothiocyanate Hydrochloride; 5 Isothiocyanatofluorescein; Fluorescein 5 isothiocyanate Hydrochloride; Hydrochloride, Fluorescein-5-isothiocyanate; Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-5-isothiocyanato-

Networked: 1026 relevant articles (17 outcomes, 82 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kurohane, Kohta: 8 articles (11/2015 - 01/2007)
2.	Imai, Yasuyuki: 8 articles (11/2015 - 01/2007)
3.	Low, Philip S: 6 articles (08/2014 - 01/2006)
4.	Baker, James R: 5 articles (04/2011 - 01/2005)
5.	Li, Ying: 4 articles (04/2014 - 01/2010)
6.	Zhang, Sheng-Hua: 4 articles (02/2014 - 07/2009)
7.	Zhang, Lin: 4 articles (12/2010 - 07/2003)
8.	Matsuda, Tomoko: 4 articles (06/2010 - 01/2007)
9.	Bacon, Kevin B: 4 articles (01/2009 - 05/2004)
10.	Moore, Bethany B: 4 articles (12/2007 - 04/2004)

Related Diseases

1.	Ischemia 09/01/1989 - "After determination of baseline data, the muscle was made ischemic for 2 hr by clamping its vascular pedicle, and subsequently reperfused for 2 hr. Ischemia-reperfusion produced a marked increase in clearance of FITC-Dx 150. " 07/01/1995 - "In saline-treated animals, ischemia-reperfusion increased the clearance of FITC-Dx 150 from 1.8 +/- 0.3 to 9.7 +/- 1.0 microliters/15 min/g by the end of the reperfusion period. " 07/01/1995 - "After determination of baseline data, the muscle was made ischemic for 4 hr by clamping the vascular pedicle and subsequently reperfused for 2 hr. In control animals not subjected to ischemia, clearance of FITC-Dx 150 remained constant throughout the experimental 7-hr period. " 05/01/1987 - "Clearance of FITC-Dx 150 increased from a control value (mean +/- SE) of 8.3 +/- 2.7 to 29.9 +/- 8.1 microliters/min/g after reperfusion following a 30-min period of ischemia, and from a control value of 36.2 +/- 13.6 to 274 +/- 94.5 after 2 hr of ischemia. " 02/20/2013 - "Transcardial perfusion of FITC-labeled albumin suggested that local ischemia was at least in part the cause of this myelination failure. "
2.	Neoplasms (Cancer) 09/01/2006 - "The cleared tumors were imaged in three modes (i) optical-CT to image the 3D distribution of microvasculature as indicated by absorbing dye, (ii) optical-ECT using the FITC excitation and emission filter set, to determine microvasculature as indicated by lectin-endothelial binding, and (iii) optical-ECT using the DSRed2 filter set to determine the 3D distribution of viable tumor as indicated by RFP emission. " 01/01/2015 - "Fluorescence microscopic studies indicated that the FITC-labeled K4R2-Nal2-S1 preferentially binds cancer cells and causes apoptotic cell death. " 04/01/2010 - "In vivo imaging study showed that FITC-labeled Ec-LDP-Hr was targeted and accumulated in the tumors. " 11/03/2015 - "Meta analyses revealed free intraperitoneal tumor cells (FITC) to be associated with poor overall survival in univariate (HR 3.27; 95% CI 2.82 - 3.78]) and multivariate (HR 2.45; 95% CI 2.04 - 2.94) analysis and poor peritoneal recurrence free survival in univariate (4.15; 95% CI 3.10 - 5.57) and multivariate (3.09; 95% CI 2.02 - 4.71) analysis. " 04/01/2015 - "Altogether, the FITC-D tumor to normal tissue ratio was significantly higher in the 10 J/cm(2) group compared others. "
3.	Inflammation 01/01/2016 - "Synthetic BK or mBK labeled with FITC at the N-terminus was employed for discriminating between inflamed and normal cells; this method was found to be effective for detection of inflammation in live cells. " 01/01/2015 - "The present study evaluated different methods to induce gut inflammation in poultry based on FITC-d leakage. " 06/01/2015 - "In conclusion, FR, DSS, and RBD affected GIT tight junction integrity, suggesting their value for enteric inflammation models, and FITC-d may be a good indicator of permeability." 06/01/2015 - "All inflammation treatments significantly increased serum FITC-d levels at both doses. " 06/01/2015 - "Dose titration of FITC-D for optimal measurement of enteric inflammation in broiler chicks."
4.	Necrosis 07/01/2015 - "Intact cells (Annexin-5-FITC(-)/7-AAD(-)), cells with early signs of apoptosis (Annexin-5-FITC(+)/7-AAD(-)), cells with late signs of apoptosis and partially necrotic cells (Annexin-5-FITC(+)/7-AAD(+)), as well as cells with early signs of necrosis (Annexin-5-FITC(-)/7-AAD(+)) were differentiated by fl ow cytometry. " 02/01/2006 - "Flow cytometric analysis of annexinV-FITC/PI-stained cells showed time-related increase in apoptosis and post-apoptotic necrosis. " 03/01/2004 - "The quantity of FITC+/PI- cells corresponded to early apoptosis, while that of FITC+/PI+ cells corresponded to late apoptosis or secondary necrosis. " 02/01/2002 - "Both apoptosis and necrosis of human fetal bone marrow CD34(+) hematopoietic stem cells cultured under MH were significantly decreased as detected by MTT and flow cytometry, with three-color labeled by PE-CD(34) (+)/ FITC-AnnexinV /7AAD. " 06/24/2015 - "Annexin-V FITC and PI staining experiments confirmed that the cell inhibition was primarily due to apoptosis and not by necrosis, which was also supported by LDH release assay experiment. "
5.	Breast Neoplasms (Breast Cancer) 03/01/2013 - "Labeling signals of QD525 in both fixed and living breast cancer cells and tissue preparations were found to be significantly higher than those of FITC at 460-495 nm excitation wavelengths. " 03/01/2011 - "Furthermore, we verified the uptake of FITC-loaded OBs by the MCF-7 breast cancer cell line. " 09/01/2009 - "Purified DNA repair enzyme, OGG1, and nuclear lysates from MCF-7 breast cancer cells were incubated with double-stranded FITC-labeled wt and 8-oxo-G oligonucleotide to demonstrate the OGG1 incision assay. " 03/01/2006 - "We show that there is a partial correlation between autofluorescence and total Her-2/neu/FITC fluorescence in individual cells in the three breast cancer cell lines. " 08/15/2004 - "In contrast, transfection of DU145 cells or the T47D and MCF-7 breast cancer cell lines to express CD44s increased cell surface binding of FITC-HA and cell adherence to hBMECs. "

Related Drugs and Biologics

1.	Fluorescein (Funduscein)
2.	isothiocyanic acid
3.	Dextrans (Dextran)
4.	Annexin A5
5.	Antigens
6.	Liposomes (Liposome)
7.	Fibrinogen (Factor I)
8.	Collagen
9.	Disintegrins
10.	Inosine Triphosphate (ITP)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Drug Therapy (Chemotherapy)
4.	Quantum Dots (Quantum Dot)
5.	Photochemotherapy (Photodynamic Therapy)