[Stimulating effects of 3% acetic acid on the induction of esophageal tumors in rats].

Abstract

The probe--mediated intragastric injection of 50 mg/kg ethyl ether of N-nitrososarcosine (EENS) 5 times a week for 6 months was followed by the development of multiple tumors in 91.8% of 120 noninbred male rats supplied by a local animal farm: esophagus--85.7%, fore-stomach--73.4% and throat--22.4%. The lesions in the esophagus and the fore-stomach entry were similarly frequent (61.2-75.5%) which was matched by a much lower incidence rate (22.4%) for the remaining parts of the fore-stomach. The combined intragastric injection of 3% acetic acid (0.5 ml thrice a week) for 8 months and EENS for 6 months boosted the total frequency of neoplasms to 100% and resulted in increased multiplicity of tumor--from 9.8--10.7 for EENS alone to 14.5 for EENS + acetic acid. Most lesions occurred in the fore-stomach entry as far as the level of tumor (squamous cell carcinoma and papilloma) development, frequency and relative risk (number of tumors. v. actual number of animals) are concerned. A long--term treatment with 3% acetic acid alone was followed by chronic inflammation of the esophageal mucosa rather than tumor development.

• Authors: V A Aleksandrov, A I Novikov, M A Zabezhinskiĭ, V I Stoliarov
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 34 Issue 5 Pg. 580-7 ( 1988) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Stimuliruiushchee vliianie 3% uksusnoĭ kisloty na induktsiiu opukholeĭ pishchevoda u krys.
• PMID: 3381501 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Acetates
• Carcinogens
• Nitrosamines
• N-nitrososarcosine ethyl ester
• Acetic Acid

Topics

• Acetates (administration & dosage)
• Acetic Acid
• Animals
• Carcinogens (administration & dosage)
• Carcinoma, Squamous Cell (chemically induced, pathology)
• Drug Synergism
• Esophageal Neoplasms (chemically induced, pathology)
• Male
• Neoplasms, Experimental (chemically induced, pathology)
• Nitrosamines (administration & dosage)
• Papilloma (chemically induced, pathology)
• Rats
• Stomach Neoplasms (chemically induced, pathology)