Papilloma (Papillomatosis)

A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)

Also Known As:

Networked: 4457 relevant articles (168 outcomes, 393 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Infection
3.	Carcinoma (Carcinomatosis)
4.	Papilloma (Papillomatosis)
5.	Squamous Cell Carcinoma (Epidermoid Carcinoma)

Experts

1.	Steinberg, Bettie M: 14 articles (12/2015 - 07/2002)
2.	Christensen, Neil D: 14 articles (08/2014 - 07/2002)
3.	Tokuda, Harukuni: 11 articles (06/2012 - 06/2002)
4.	National Toxicology Program: 10 articles (02/2013 - 05/2001)
5.	Wu, Rong: 9 articles (12/2015 - 02/2002)
6.	Cladel, Nancy M: 9 articles (08/2014 - 07/2002)
7.	Zeitels, Steven M: 9 articles (09/2012 - 06/2002)
8.	Abramson, Allan L: 9 articles (04/2012 - 03/2004)
9.	Hu, Jiafen: 8 articles (08/2014 - 07/2002)
10.	Pan, Min-Hsiung: 8 articles (02/2014 - 11/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Papilloma:

1.	9,10-Dimethyl-1,2-benzanthracene (DMBA)IBA 02/19/1998 - "Furthermore, papillomas developed at a significantly greater frequency and shorter latency in the HK1.bcl-2 mice compared to control littermates following initiation with DMBA and promotion with TPA. " 02/01/1990 - "The radiation produced a dose-dependent reduction in the number of papillomas which appeared after TPA promotion, with about a 20% reduction in animals receiving 0.5 Gy surface dose just before initiation, about 50% reduction after 2.5 Gy, and greater than 80% at doses above 5 Gy. A dose of 2.5 Gy in animals initiated with DMBA produced no significant reduction. " 02/01/1988 - "In two-step carcinogenesis experiments involving treatment with DMBA and TPA to induce skin papillomas, Zyûzen-taiho-tô appeared to be effective in inhibiting carcinogenesis. " 06/28/2011 - "Transfer of B cells from DMBA/TPA-treated wild-type mice to Tnf(-/-) mice rescued papilloma development to a wild-type level, a result not observed when B cells from Tnf(-/-) mice were transferred to Rag2(-/-) mice or when TNF-α was eliminated selectively in B cells. " 08/15/2014 - "In this study, the incidence of skin papillomas induced by 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) in S100a9(-/-) mice has been investigated. "
2.	cidofovir (Vistide)FDA Link 08/01/2003 - "Topical applications of cidofovir, an antiviral compound with activity against human papilloma virus, is effective in the majority of patients with perianal condylomata and is a valuable adjuvant to surgical treatment of these lesions." 04/01/2000 - "We conclude that intralesional cidofovir appears to be a promising new treatment for controlling--and perhaps at higher dosages curing--refractory laryngeal papillomas, while causing little or no injury to laryngeal structures." 08/01/2014 - "The purpose of this study was to determine whether formulation of the small molecule acyclic nucleoside, cidofovir (CDV), could lead to improved therapeutic endpoints following topical treatment of papillomas using the cottontail rabbit papillomavirus (CRPV)/rabbit model. " 03/01/2010 - "Intralesional cidofovir injection has been shown to be an effective an safe therapy for laryngeal papilloma and should be considered in those patients who experienced disease relapse." 07/01/2008 - "Although results of case series suggest that cidofovir may decrease the frequency and rapidity of papilloma regrowth, no blinded placebo-controlled studies have demonstrated efficacy. "
3.	DNA (Deoxyribonucleic Acid)IBA 10/01/2008 - "Our observations suggest that human papilloma virus (HPV) 6/11 is the main causative agent of laryngeal papilloma and that detection of active HPV DNA expression may be helpful in identifying patients with aggressive recurrent laryngeal papilloma. " 06/01/2003 - "This study was carried out to evaluate the efficacy of HPV-DNA (Human Papilloma Virus) testing as a triage strategy for persistent borderline and mild cytological abnormalities. " 03/01/2006 - "Cervical/endocervical cytology screening has decreased morbidity and mortality, and implementing adjunctive human papilloma virus (HPV) DNA testing for atypical squamous cells of undetermined significance has improved the specificity for detecting premalignant squamous lesions. " 01/01/2004 - "No CRPV DNA was detected either in the regression sites or in sites that did not form papillomas, indicating that the vaccination led to clearance of CRPV from all infected sites." 03/01/2003 - "Although PCR and DNA probe hybridization for human papilloma virus (HPV) types 2, 6/11, 16 and 18 failed to reveal positive results, the location and clinicopathologic correlation convinced us that superimposed HPV could not be excluded."
4.	InterferonsIBA 03/01/2012 - "Interferon has been previously reported as an effective treatment for conjunctival papillomas. " 09/01/1988 - "Interferon is very useful in treating papillomas and condylomas, and its role as a local agent will probably expand. " 10/01/1999 - "One patient showed an improvement in papilloma stage that was possibly related to concurrent therapy with interferon. " 09/01/1991 - "The efficacy of interferon therapy of airways papillomatosis can be further increased, if doses are selected on an individual basis." 06/01/1989 - "A clinical study on 20 patients with uterine cervix Human Papilloma Virus (HPV) lesions treated with intralesional recombinant alpha 2b interferon (3 millions I.U.) three times a week for three weeks where possible, is presented. "
5.	TeaIBA 01/01/1998 - "In separate experiments, there was a significant dose response to black tea as a preventive against UV-related skin lesions, and also consumption of black tea was associated with a small but significant reduction in the incidence of papillomas in mice previously exposed to UV radiation. " 11/01/1997 - "Mice with established papillomas were then treated with black tea or decaffeinated black tea (approximately 4 mg tea solids/ml) as the sole source of drinking fluid for 11-15 weeks. " 01/01/1994 - "Green tea extract has also been shown to cause partial regression of established skin papillomas in mouse. " 12/01/1992 - "In 10 separate experiments, mice with established chemically induced or UV light-induced skin papillomas were treated continuously with green tea in the drinking water or with i.p. " 12/01/1992 - "Inhibitory effect of green tea on the growth of established skin papillomas in mice."
6.	anthraceneIBA 01/01/1992 - "This study was designed to evaluate the point mutations in the murine c-Ha-ras gene of skin papillomas induced by initiation with dibenz[a,j]anthracene (DB[a,j]A), its bay-region anti-diol epoxide ((+/-)anti-DB[a,j]A-DE), and a 7,14-dimethyl analogue (7,14-diMeDB[a,j]A). " 01/01/2012 - "Further, its efficacy was evaluated against di-methyl benzo anthracene-induced skin papilloma in Swiss albino mice. " 04/01/2010 - "STAT2 deficiency also inhibited 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced skin carcinogenesis as indicated by reduced papilloma multiplicity. " 02/01/2005 - "In addition, IH-901 given prior to each topical dose of TPA markedly lowered the number of papillomas in mouse skin induced by 7,12-dimethylbenz[a]anthracene. " 12/01/2001 - "Because 7,12-dimethylbenz[a]anthracene induces an activating mutation of H-ras, this provides one possible explanation for suppression of papilloma formation when FAK protein is limiting."
7.	VaccinesIBA 03/20/2014 - "Existing vaccines against hepatitis B virus (HBV) and human papilloma virus 16, 18, 6 and 11 are highly efficacious and cost effective. " 03/01/2015 - "Human papilloma virus (HPV) vaccination rates in the United States remain low, compared with other recommended adolescent vaccines. " 01/01/2015 - "Human papilloma virus-like particles (HPV VLP) serve as the basis of the current licensed vaccines for HPV. " 01/01/2014 - "Awareness and attitude relating to the human papilloma virus and its vaccines among pediatrics, obstetrics and gynecology specialists in Turkey." 12/02/2013 - "Impact of medical education on knowledge and attitudes regarding the human papilloma virus and vaccination: comparison before and 6 years after the introduction of the vaccines."
8.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 07/01/2015 - "Preoperative PDT is beneficial for reducing the lesion in diffuse or multifocal biliary papillomatosis and may lead to curative and volume reserving surgery. " 03/01/1992 - "At this time, no studies have investigated the effects of pulsed light during PDT on virally induced papillomas. " 07/01/2015 - "Thus, PDT could improve the quality of life and prolong life expectation for biliary papillomatosis patients. " 07/01/2015 - "This is the first case report on PDT for biliary papillomatosis in Korea. " 01/01/2015 - "Among 63 mouse papillomas treated with Pa-mediated PDT, 17.5% of the lesions were completely removed 1 week after the first treatment, while 31.7% disappeared 1 week after the second treatment. "
9.	AntigensIBA 10/01/2004 - "Superior therapeutic efficacy of alphavirus-mediated immunization against human papilloma virus type 16 antigens in a murine tumour model: effects of the route of immunization." 02/01/2008 - "In this study, we investigated the up-regulation of major histocompatibility complex (MHC) class I surface expression on tumour cells by epigenetic mechanisms using a murine tumour cell line expressing human E6 and E7 human papilloma virus 16 (HPV16) oncogenes and deficient in MHC class I expression, as a result of impaired antigen-presenting machinery (APM). " 01/01/1986 - "The present study was undertaken with purpose to investigate the relationships between intraepithelial proliferations of malpighian mucosa and the presence of group specific papilloma virus antigens. " 10/01/1984 - "Immunohistochemical study of similar areas disclosed human papilloma structural antigens in the lesions in 60%, while 50% had lesions in which human papilloma virions were detected by the electron microscope. " 01/01/1984 - "More than 70% of the women younger than 25 years had condylomata, as judged from colposcopy, histologic study and test for human papilloma virus antigen. "
10.	Laryngeal papillomatosisIBA 07/01/1993 - "Recurrent laryngeal papillomatosis: a case of florid papillomatosis following a remission of 30 years." 01/01/2013 - "The objective of the present study was to estimate the state of the problem of laryngeal papillomatosis in the adult patients, analyse the structure of papillomatosis morbidity, summarize the available information on the clinical features of this pathology and outcomes of its hospital-based treatment. " 10/01/2003 - "In this study, among 90 patients treated for laryngeal papillomatosis, in four children papilloma of trachea, bronchi and lung tissue were detected in endoscopic and radiological examination. " 02/01/2015 - "Authors present a case report of a 2-year-old boy with recurrent laryngeal papillomatosis with oesophageal involvement due to human papilloma virus types 6 and 11, who needed surgical treatment every 4-6 weeks, altogether 11 times. " 02/01/2015 - "Recurrent laryngeal papillomatosis with oesophageal involvement in a 2 year old boy: successful treatment with the quadrivalent human papillomatosis vaccine."

Therapies and Procedures

1.	Laser Therapy (Surgery, Laser) 02/01/2015 - "This study evaluated the therapeutic efficacy of laser therapy in treating oral human papilloma virus (HPV) lesions. " 01/01/2007 - "The therapeutic treatment of choice in larynx-obstructing papillomatosis is at present surgical laser ablation. " 06/01/2009 - "To study and evaluate the feasibility and effect of the treatment for juvenile recurrent laryngeal papilloma by nasal endoscopy electric suction cutting and laser surgery. " 09/01/2008 - "A case of isolated tracheal papillomas recurring 15 years following laser surgery is reported. " 02/01/2008 - "Surgical debulking of papillomas is currently the treatment of choice; newer surgical approaches utilizing microdebriders are replacing laser ablation. "
2.	Lasers (Laser) 08/01/1990 - "[Laser flow cytofluorimetry in the study of papilloma virus-induced lesions]." 01/01/1985 - "Effectiveness of lasers on plantar papillomas: a preliminary study." 10/01/2013 - "Oral squamous papillomas can be found in child's oral cavity and laser dentistry can be used by dental clinicians to treat these kinds of oral lesions and should be considered as an alternative to conventional surgery. " 10/01/2013 - "The aim of this report is to present the oral squamous papilloma in a pediatric patient and its treatment with soft tissue laser. " 10/01/2013 - "Laser treatment of an oral squamous papilloma in a pediatric patient: a case report."
3.	Gas Lasers 04/01/2003 - "All patients were treated with CO2 laser therapy, but there was complete remission of the papillomas in only two cases." 10/20/1991 - "The CO2 laser has improved the quality of treatment of laryngeal papilloma. " 01/01/2003 - "For the 6-month study, patients for whom removal of recurrent respiratory papillomas was indicated were randomly assigned by birth year to microdebrider or CO2 laser therapy. " 11/01/1996 - "The purpose of this study was to determine the potential risk of transmitting viable viral infected cells as well as viral infectivity of laryngeal papilloma in the plume derived from a continuous mode carbon dioxide laser. " 08/01/2014 - "Eight patients with laryngeal papilloma were excised by CO2 laser. "
4.	Cryotherapy (Therapy, Cold) 11/01/2013 - "Adjunct cryotherapy was also performed at the time of the surgery to try to stem the recurrence of the papillomas. " 04/01/2003 - "One patient with a conjunctival papilloma and one patient with a limbus-based papilloma were treated with excision and cryotherapy. " 11/01/2002 - "We report a 26-year-old man with recurrent conjunctival papilloma despite repeated surgical excision, cauterization, and cryotherapy. " 09/01/1999 - "An 11-year-old boy had an 8-year history of diffuse conjunctival papillomas, treated previously with standard measures of excisional biopsy and cryotherapy. " 01/01/1997 - "Cryotherapy of papilloma is thought ineffective."
5.	Dye Lasers 02/01/2007 - "Efficacy of treating children with anterior commissure and true vocal fold respiratory papilloma with the 585-nm pulsed-dye laser." 06/01/2002 - "585-nm pulsed dye laser treatment of glottal papillomatosis." 12/01/1998 - "Flash pump dye laser treatment of laryngeal papillomas." 07/01/1998 - "A 585-nanometer pulsed dye laser treatment of laryngeal papillomas: preliminary report." 04/01/2004 - "Office-based treatment of glottal dysplasia and papillomatosis with the 585-nm pulsed dye laser and local anesthesia."