Abstract | BACKGROUND/AIM: It has been hypothesized that many, or even most cancers, utilize a unique immunomodulatory protein, called the progesterone induced blocking factor (PIBF) to allow spread of the cancer. Support for this concept has been provided by cancer cell line studies showing that PIBF is produced by these cancer cells and mifepristone suppresses this protein and inhibits proliferation of these cells. Furthermore, controlled murine studies with several spontaneous different types of cancer showed a clear beneficial effect of mifepristone over placebo control. Finally, there have been a variety of anecdotal reports showing efficacy of mifepristone in providing increased length and quality of life in patients with different types of advanced cancers. CASE REPORT: CONCLUSION:
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Authors | Jerome H Check, Diane Check, Trina Poretta, Carrie Wilson |
Journal | Anticancer research
(Anticancer Res)
Vol. 41
Issue 4
Pg. 2111-2115
(Apr 2021)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 33813421
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
Chemical References |
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Topics |
- Administration, Oral
- Bone Neoplasms
(drug therapy, pathology)
- Cancer Pain
(drug therapy)
- Humans
- Male
- Middle Aged
- Mifepristone
(administration & dosage)
- Neoplasm Metastasis
- Osteosarcoma
(drug therapy, pathology)
- Palliative Care
(methods)
- Quality of Life
- Tibia
- Treatment Outcome
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