Nox2 up-regulation and hypoalbuminemia in patients with type 2 diabetes mellitus.

Abstract

Type 2 diabetes mellitus (T2DM) is associated with oxidative stress but the underlying mechanisms promoting oxidative stress as well as its relationship with cardiovascular events is still unclear. In 375 T2DM patients who were followed-up for approximately 5 years we measured the serum levels of soluble NOX2-derived peptide (sNOX2-dp), a marker of Nox2 activation, and albumin, a powerful antioxidant protein. In the entire cohort soluble Nox2 and serum albumin were significantly correlated (r = -0.348, P < 0.0001). During the follow-up 49 cardiovascular events (CVE) were registered, of which 45 were non-fatal myocardial infarction (MI); patients with non-fatal MI had significantly higher soluble NOX2/albumin ratio compared to cardiovascular events-free patients. Cox regression analysis showed a significant association between sNox2-dp/serum albumin ratio and the incidental risk of non-fatal MI (HR 1.106, CI95% 1.020-1.198, P = 0.014). The study suggests that redox status imbalance negatively influences vascular outcomes in T2DM.

• Authors: Elena Succurro, Francesco Andreozzi, Roberto Carnevale, Angela Sciacqua, Vittoria Cammisotto, Velia Cassano, Gaia C Mannino, Teresa V Fiorentino, Daniele Pastori, Pasquale Pignatelli, Giorgio Sesti, Francesco Violi
• Journal: Free radical biology & medicine (Free Radic Biol Med) Vol. 168 Pg. 1-5 (05 20 2021) ISSN: 1873-4596 [Electronic] United States
• PMID: 33775771 (Publication Type: Journal Article)
• Copyright: Copyright © 2021. Published by Elsevier Inc.

Chemical References

• Membrane Glycoproteins
• NADPH Oxidase 2
• NADPH Oxidases

Topics

• Diabetes Mellitus, Type 2 (complications)
• Humans
• Hypoalbuminemia
• Membrane Glycoproteins
• NADPH Oxidase 2 (genetics, metabolism)
• NADPH Oxidases (genetics)
• Up-Regulation