Short-term effects of gonadotropin-releasing hormone analogue treatment on leptin, ghrelin and peptide YY in girls with central precocious puberty.

Abstract

OBJECTIVES:

To determine appetite-regulating hormone levels in girls with central precocious puberty (CPP) before and after 20 weeks of gonadotropin-releasing hormone analogue (GnRH-A) treatment.

METHODS:

Eighteen newly diagnosed CPP girls were enrolled. Body composition measured by bioelectrical impedance analysis and GnRH-A test were performed with fasting serum leptin, ghrelin and peptide YY (PYY) measurements at baseline (before) and after 20 weeks of GnRH-A treatment.

RESULTS:

Following GnRH-A treatment, all patients had prepubertal gonadotropin and estradiol levels. Mean (SD) fat mass index (FMI) was significantly increased from 4.5 (1.7) to 5.0 (1.8) kg/m2 after treatment. Also, median (IQR) serum leptin level was significantly increased from 6.9 (4.2-8.6) to 7.4 (5.3-13.1) ng/mL. FMI had a positive correlation with serum leptin level (r=0.64, p=0.004). In contrast, no significant changes of serum ghrelin and PYY levels were observed.

CONCLUSIONS:

Decreased estrogen following short-term GnRH-A treatment in CPP girls may cause an increase in appetite and consequently an elevation of FMI. Increased serum leptin may be a result of having increased FMI secondary to an increase in appetite.

• Authors: Piyathida Wijarn, Preamrudee Poomthavorn, Patcharin Khlairit, Sarunyu Pongratanakul, Laor Chailurkit, Pat Mahachoklertwattana
• Journal: Journal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 34 Issue 4 Pg. 479-484 (Apr 27 2021) ISSN: 2191-0251 [Electronic] Germany
• PMID: 33655737 (Publication Type: Journal Article)
• Copyright: © 2021 Walter de Gruyter GmbH, Berlin/Boston.

Chemical References

• Ghrelin
• Gonadotropins
• Leptin
• Peptide YY
• Gonadotropin-Releasing Hormone
• Estradiol

Topics

• Adiposity
• Appetite (drug effects)
• Body Composition
• Body Mass Index
• Child
• Estradiol (blood)
• Female
• Ghrelin (metabolism)
• Gonadotropin-Releasing Hormone (adverse effects, analogs & derivatives, therapeutic use)
• Gonadotropins (blood)
• Humans
• Leptin (metabolism)
• Peptide YY (metabolism)
• Puberty, Precocious (drug therapy, metabolism)