Abstract | BACKGROUND & AIMS: Late recurrence of hepatocellular carcinoma (HCC) is regarded as de novo HCC from chronic hepatitis. This study investigated clinicopathological and molecular factors to develop a nomogram for predicting late HCC recurrence (>2 years after curative resection). METHODS: RESULTS: Late recurrence occurred in 74/402 (18%) and 47/243 (19%) in the training and validation cohorts respectively. Cirrhosis, moderate/severe lobular inflammatory activity, and expression of pSTAT3, pERK1/2, and SYK proteins correlated to the gene signature of hepatocyte injury and regeneration were independently associated with late recurrence, with odds ratios (95% confidence intervals) of 2.0 (1.2-3.3), 21.1 (4.3-102.7) and 6.0 (2.1-17.7) respectively (P < .05 for all). A nomogram based on these variables (histological parameters and immunohistochemical marker combinations) showed high reliability in both the training and validation cohorts (Harrell's C index: 0.701 and 0.716; 95% confidence intervals: 0.64-0.76 and 0.64-0.79 respectively). CONCLUSIONS: The combination of pSTAT3, pERK1/2 and SYK immunoexpression with high lobular inflammatory activity and cirrhosis ( fibrosis) predicts late HCC recurrence.
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Authors | Ji Hae Nahm, Hye Sun Lee, Haeryoung Kim, Sun Young Yim, Ji-Hyun Shin, Jeong Eun Yoo, Sang Hoon Ahn, Jin Sub Choi, Ju-Seog Lee, Young Nyun Park |
Journal | Liver international : official journal of the International Association for the Study of the Liver
(Liver Int)
Vol. 41
Issue 7
Pg. 1662-1674
(07 2021)
ISSN: 1478-3231 [Electronic] United States |
PMID | 33638929
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Topics |
- Carcinoma, Hepatocellular
(surgery)
- Hepatectomy
- Humans
- Liver Neoplasms
(surgery)
- Neoplasm Recurrence, Local
- Reproducibility of Results
- Retrospective Studies
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