MicroRNAs and Diabetes Mellitus Type 1.

Abstract

Type 1 diabetes mellitus is a multifactorial, progressive, autoimmune disease with a strong genetic feature that can affect multiple organs, including the kidney, eyes, and nerves. Early detection of type 1 diabetes can help critically to avoid serious damages to these organs. MicroRNAs are small RNA molecules that act in post-transcriptional gene regulation by attaching to the complementary sequence in the 3'-untranslated region of their target genes. Alterations in the expression of microRNA coding genes are extensively reported in several diseases, such as type 1 diabetes. Presenting non-invasive biomarkers for early detection of type 1 diabetes by quantifying microRNAs gene expression level can be a significant step in biotechnology and medicine. This review discusses the area of microRNAs dysregulation in type 1 diabetes and affected molecular mechanisms involved in pancreatic islet cell formation and dysregulation in the expression of inflammatory elements as well as pro-inflammatory cytokines.

• Authors: Farbod Bahreini, Elham Rayzan, Nima Rezaei
• Journal: Current diabetes reviews (Curr Diabetes Rev) Vol. 18 Issue 2 Pg. e021421191398 ( 2022) ISSN: 1875-6417 [Electronic] United Arab Emirates
• PMID: 33588736 (Publication Type: Journal Article, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Biomarkers
• MicroRNAs

Topics

• Biomarkers
• Diabetes Mellitus, Type 1 (genetics)
• Gene Expression Regulation
• Humans
• MicroRNAs (genetics, metabolism)