Abstract | PURPOSE: METHODS: RESULTS: It was found that diabetes led to an increase in neopterin and NO levels, and a decrease in BH4 levels. A stimulation was observed in eNOS gene expression in the GDM group when compared to the control group, while GCHI levels were found to decrease when compared to the control group. iNOS gene expression was detected in neither the healthy controls nor the patient group. CONCLUSIONS: Decreased NO bioavailability plays an important role in the progression of such macrovascular diseases as diabetes. BH4 levels decrease in diabetes patients, while the increased gene expression of GCHI reverses the diabetes-related BH4 deficiency and allows the endothelial cells to regain their ability to produce NO. Since GCHI is the rate-limiting enzyme in the biosynthesis of BH4, changes in GCHI levels directly affect the BH4 levels and the NO metabolism, leading to an increased risk of macrovascular complications. The significant increase in neopterin levels suggest that this is a potential biomarker for the early diagnosis of GDM.
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Authors | Songül Ünüvar, Rauf Melekoğlu, Emine Şalva, Ceren Acar, Şeyma Yaşar |
Journal | Journal of diabetes and metabolic disorders
(J Diabetes Metab Disord)
Vol. 19
Issue 2
Pg. 1391-1396
(Dec 2020)
ISSN: 2251-6581 [Print] Switzerland |
PMID | 33520842
(Publication Type: Journal Article)
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Copyright | © Springer Nature Switzerland AG 2020. |