Percutaneously-quantified advanced glycation end-products (AGEs) accumulation associates with low back pain and lower extremity symptoms in middle-aged low back pain patients.
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| Abstract |
Advanced glycation end-products (AGEs) have been reported as a possible biomarker of ageing and metabolic diseases; however, its role in the clinical progression of these diseases remains unclear. We aimed to evaluate how AGEs are associated with clinical symptoms and comorbidities in lower back pain (LBP) patients. This prospective cohort study enrolled 636 LBP patients. They were subjected to quantified AGE (qAGE) analysis using skin autofluorescence, and their clinical symptoms and comorbidities, such as diabetes, renal failure with haemodialysis treatment, and osteoporosis, were measured. LBP, lower extremity pain, and numbness were evaluated using a visual analogue scale (VAS). The measured qAGE was significantly higher in subjects with any comorbidity. Age also showed a strong positive correlation with qAGE. qAGE and VAS for leg numbness were positively correlated. Furthermore, in LBP patients under 50-years-old, qAGE was positively correlated with VAS for LBP, lower extremity pain, and numbness. In conclusion, qAGE, as measured by skin autofluorescence measurement, was significantly higher in LBP patients with diabetes and dialysis, as well as in osteoporosis patients. Furthermore, qAGE showed potential as a biomarker for LBP, lower extremity pain, and numbness in patients under 50-years-old. If accumulated AGEs are identified at a young age, researchers should be vigilant for the development of osteoporosis and LBP-related clinical symptoms later in life.
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| Authors | Tomotaka Umimura, Sumihisa Orita, Kazuhide Inage, Yasuhiro Shiga, Satoshi Maki, Masahiro Inoue, Hideyuki Kinoshita, Masaki Norimoto, Takashi Sato, Masashi Sato, Masahiro Suzuki, Keigo Enomoto, Takashi Hozumi, Norichika Mizuki, Hiromitsu Takaoka, Geundong Kim, Junichi Nakamura, Shigeo Hagiwara, Tsutomu Akazawa, Hiroshi Takahashi, Masao Koda, Takeo Furuya, Yuki Shiko, Yohei Kawasaki, Seiji Ohtori |
| Journal | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 84 Pg. 15-22 (Feb 2021) ISSN: 1532-2653 [Electronic] Scotland |
| PMID | 33485592 (Publication Type: Journal Article) |
| Copyright | Copyright © 2020 Elsevier Ltd. All rights reserved. |
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