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Hypesthesia (Numbness)

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Absent or reduced sensitivity to cutaneous stimulation.

Also Known As:

Numbness; Hypoesthesia; Impaired Sensation; Reduced Sensation; Hypesthesias; Hypesthesias, Tactile; Hypesthesias, Thermal; Hypoesthesias; Impaired Sensations; Reduced Sensations; Sensation, Impaired; Sensation, Reduced; Sensations, Impaired; Sensations, Reduced; Tactile Hypesthesia; Tactile Hypesthesias; Thermal Hypesthesia; Thermal Hypesthesias; Hypesthesia, Tactile; Hypesthesia, Thermal

Networked: 1111 relevant articles (92 outcomes, 62 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Paresthesia (Dysesthesia)
3.	Hypesthesia (Numbness)
4.	Headache (Headaches)
5.	Dizziness (Lightheadedness)

Experts

1.	Ueki, Koichiro: 7 articles (12/2014 - 08/2003)
2.	Marukawa, Kohei: 6 articles (12/2014 - 02/2007)
3.	Régis, Jean: 4 articles (12/2014 - 10/2007)
4.	Liu, Jun: 4 articles (01/2013 - 10/2011)
5.	Nakagawa, Kiyomasa: 4 articles (01/2008 - 08/2003)
6.	Loprinzi, Charles L: 3 articles (02/2016 - 06/2011)
7.	Mols, Floortje: 3 articles (09/2015 - 07/2013)
8.	van de Poll-Franse, Lonneke V: 3 articles (09/2015 - 07/2013)
9.	Beck, Mike: 3 articles (01/2015 - 02/2004)
10.	Reader, Al: 3 articles (01/2015 - 02/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypesthesia:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 09/01/2005 - "Therapy with corticosteroids resulted in a complete remission in November 2000 except for a persistent numbness of the left side of her face and body and reduced visual acuity on both sides. " 08/07/1993 - "Six weeks after treatment with external fixation and corticosteroids the situation had improved markedly, with remaining hypesthesia in both hands and the right leg." 07/01/2007 - "The patient underwent treatment with corticosteroids, and after 2 months, the clinical examination revealed an improved clinical situation with a disappearance of the hypoesthesia but with a persistence of the pain. " 01/01/2013 - "There were significant relations between: antimetabolite chemotherapeutics and feeling irritable and worrying (p=0.001, p=0.030); vinkoalkaloid and numbness/tingling in hands/feet (p=0.043); antracyclines and lack of energy and skin changes (p=0.021, p=0.004); and corticosteroids and lack of appetite, nausea and sadness (p=0.008, p=0.009, p=0.009). " 01/01/2008 - "During the fifth cycle, he experienced a grade 2 hypersensitivity reaction including erythema and lip numbness, for which he was medicated with antihistaminics and corticosteroids. "
2.	Amitriptyline (Elavil)FDA LinkGeneric 02/01/1988 - "A 54 year old man on oral amitriptyline 150 mg uninterruptedly for 2 years consulted us for lower limb paresthesias and was found on clinical examination to have reduced ankle jerks and mild distal global hypoesthesia. " 01/01/2008 - "This double-blind, randomized, placebo-controlled study assessed the efficacy of low-dose amitriptyline to relieve chemotherapy-induced symptoms in 44 patients (age 20-65 years) who had neuropathic symptoms (numbness, tingling, pain) with a severity of > or =3/10. " 01/01/2013 - "The combined amitriptyline + magnesium citrate treatment proved effective on all parameters except numbness. " 07/01/2005 - "Ninety-two patients with diabetic neuropathy, postherpetic neuralgia, or postsurgical/posttraumatic neuropathic pain with allodynia, hyperalgesia, or pinprick hypesthesia were randomly assigned to receive one of four creams (placebo, 2% amitriptyline, 1% ketamine, or 2% amitriptyline-1% ketamine combined). " 01/01/1982 - "The same number of TES occurred for each group with seven unique to viloxazine (numbness, tingling, palpitation, ejaculation difficulty, nausea/vomiting, diarrhea, epigastric pain and gustatory disturbances) and seven unique to amitriptyline (insomnia, irritability, syncope, tremor, nasal congestion, orthostatic hypertension and paroxysmal atrial tachycardia). "
3.	Glutamine (L-Glutamine)FDA Link 06/01/2005 - "Patients who received glutamine developed significantly less weakness (P = 0.02), less loss of vibratory sensation (P = 0.04) and less toe numbness (P = 0.004) than controls. " 05/01/2001 - "For patients who received glutamine, there was a statistically significant reduction in the severity of peripheral neuropathy as measured by development of moderate to severe dysesthesias and numbness in the fingers and toes (P < 0.05). " 10/01/2008 - "Two studies revealed that oral glutamine was effective in reducing peripheral neuropathy associated with high-dose paclitaxel, as evidenced by a reduction in numbness, dysesthesias, and motor weakness, as well as a smaller loss of vibratory sensation. "
4.	CosmeticsIBA 06/01/2013 - "The group of children who underwent surgery without thinning and with shorter follow-up time experienced fewer complications, shorter time for surgery, minimized healing time, no numbness, and improved cosmetic appeal in comparison with the group that underwent the traditional skin thinning procedure. " 04/01/2015 - "The postoperative cosmetic result was satisfactory, with minimal numbness and tingling on the anterior chest. " 01/01/2015 - "No severe skin problems, numbness around the implant, or cosmetic problems arose. " 04/01/2013 - "No patients experienced hair loss, significant numbness, cosmetic defects, or intraoperative or audiologic complications. " 02/01/2013 - "There were no postoperative swelling, numbness or other kinds of uncomfortableness with benign patients and they were satisfied with the cosmetic outcomes. "
5.	Methylprednisolone FDA LinkGeneric 09/01/2011 - "Subsequently, although left vision improved to 0.4, numbness of the hands and feet appeared during methylprednisolone therapy. " 01/01/2012 - "After the treatment with methylprednisolone and standard immunosuppressive therapy, her rashes resolved, there were no acute asthma attacks, and the numbness in her lower limbs improved." 02/01/1993 - "A 47-year-old female patient with chronic inflammatory demyelinating polyneuropathy started to recover from her numbness and weakness within a few hours following the commencement of intravenous methylprednisolone 1,000 mg. In parallel with the recovery of muscle strength, a prolonged latency time of the M-wave was normalized within a day by a revival of the new motor units with a normal latency. " 03/01/1992 - "For example, treatment with methylprednisolone more than doubled the probability that patients would convert from quadriplegia or paraplegia to quadriparesis or paraparesis, analgesia to hypalgesia, and anesthesia to hypesthesia. "
6.	Ganciclovir (Cytovene)FDA LinkGeneric 01/01/2015 - "While his meningitic symptoms gradually improved after intravenous administration of ganciclovir, he complained of numbness in the extremities and difficulty in walking. " 07/01/1998 - "Ganciclovir (daily dose: 400 mg, every 12 h) was administered for two weeks, but the painful numbness gradually extended to the trunk. " 03/01/1994 - "Ganciclovir (DENOSINE, TANABE SEIYAKU CO., LTD., Osaka, Japan) therapy given for 4 weeks produced a marked improvement in the ocular fundal findings, but the neurologic signs and symptoms, including headache, hypoesthesia, disorientation, and dementia became worse. "
7.	Alprostadil (Muse)FDA LinkGeneric 06/01/2004 - "Administration of Lipo-PGE1 improved subjective symptoms especially in items of numbness and imperception. " 07/01/1994 - "Patients who received PGE1 showed a significant improvement rate in pain and hypesthesia compared to patients in groups A and B, and in numbness compared to group A. " 08/01/1994 - "The effectiveness was similar to Lipo PGE1, but the complications such as hypotension, headache, and numbness were more common in PGI2."
8.	Serotonin (5 Hydroxytryptamine)IBA 06/01/2003 - "Visual analog scales of low back pain, sciatic pain, and numbness were significantly improved after the administration of the serotonin 5-HT(2A) receptor blocker. " 02/01/2007 - "Sarpogrelate, an antiplatelet agent with selective 5-hydroxytryptamine (5-HT) receptor 2A antagonist activity, has been reported to improve low back pain, sciatica, and numbness of lower extremities in patients with lumbar disc herniation. "
9.	ONO 2235 (epalrestat)IBA 07/01/2006 - "Numbness of limbs, sensory abnormality, and cramping improved significantly with epalrestat versus the control group. " 05/01/1995 - "Subjective symptoms, such as spontaneous pain in the lower extremities and numbness and hypoesthesia of the extremities or trunk, were significantly (P < 0.001) relieved after 12 and 24 weeks of epalrestat treatment. "
10.	Lidocaine (Xylocaine)FDA LinkGeneric 06/01/2012 - "In 10 of 12 healthy controls, a cool hypoesthesia area developed in the groin after the lidocaine block. " 02/01/2012 - "Topical lidocaine (5%) induces thermal hypoesthesia and pinprick hypoalgesia, suggesting an isolated but only partial block of Aδ and C fibers of unpredictable extent. " 05/01/2008 - "In the absence of CSF flow, 0.25 mL 2% lidocaine was injected to elicit hypesthesia in the affected side. " 02/01/2006 - "The lidocaine group reported significantly more symptoms (ie, oral numbness and tingling) than the saline group (saline 0/39, lidocaine 16/38, 42%, P < .01). " 03/01/1988 - "One patient in group 2 experienced transient numbness of the right hand, a possible side effect of lidocaine. "

Therapies and Procedures

1.	Anesthesia 01/18/2014 - "Two of the fingers presented anesthesia preoperatively, which improved to hypesthesia postoperatively. " 11/01/2015 - "One patient experienced bothersome numbness and 2 patients developed anesthesia dolorosa. " 09/01/2015 - "Forty-five (93.8%) had hypoesthesia and three (6.2%) had anesthesia (p = 0.006). " 07/01/2015 - "The anesthesia was considered unsuccessful if there was a positive EPT response ten minutes following profound lip numbness. " 07/01/2015 - "Mean onset times of pulpal anesthesia, soft tissue and lip numbness were analyzed with Log-Rank test. "
2.	Aftercare (After-Treatment) 08/01/2012 - "After treatment, the symptoms and signs of patients have significantly improved (P < 0.01), but the symptomes of powerless urination and defecation,numbness in perineum was not improved obviously (P>0.05). " 05/01/2011 - "Numbness occurred in unilateral lower extremity of 1 case postoperatively, and the symptom was relieved completely after treatment of detumescence and neural nutrition. " 01/01/2014 - "The actuarial probability of hypoesthesia onset at 6 months was 4.3%; at 1 year it reached 13% and remained stable until 13 years after treatment. " 06/01/2012 - "The patient remains free of recurrence with mild hypoesthesia of the third trigeminal branch 5 years after treatment. " 05/01/2012 - "27 of 32 (84.4%) cases with femoral nerve injury got quadriceps strength above 4/5 grade, 20 cases of femoral nerve injury (62.5%) still had numbness on front of their thigh after treatment. "
3.	Drug Therapy (Chemotherapy) 12/01/2014 - "Of all 191 women, the 129 women who received chemotherapy more often reported having tingling hands/feet and feeling numbness in fingers/toes, specifically 51% reported "a little" to "very much" of these symptoms vs. about 27% who did not receive chemotherapy. " 07/01/2010 - "However, the patient developed digital numbness within 8 courses and single-agent chemotherapy with S-1 was restarted. " 09/01/2009 - "While regenerating bone marrow following induction chemotherapy, she complained of numbness in the lower legs and then became unable to walk. " 07/01/2007 - "After 5 months of the last cycle of the chemotherapy, his left eyelid began to droop, left eye movements became limited, and he began experiencing numbness of his right forehead and cheek. " 04/01/2007 - "We report the findings of spinal magnetic resonance imaging (MRI) in 2 patients who had undergone intrathecal chemotherapy and presented with the subacute onset of ascending numbness and weakness. "
4.	Decompression 05/01/2009 - "We conclude that combined endoscopic and transconjunctival orbital decompression offers equivalent efficacy with less postoperative infraorbital hypesthesia and early rhinosinusitis than does combined endoscopic and transantral orbital decompression." 01/01/1994 - "While hypesthesia improved after decompression, the other sensory deficits were stabilized in 5% of the patients. " 05/01/1997 - "Many recent reports of the results of decompression of the median nerve in the carpal tunnel have concentrated on only one aspect of recovery (numbness, grip etc.), and there are no reports of a comprehensive study of outcome. " 10/01/2014 - "The authors report a case of trigeminal hypesthesia caused by compression of the spinal cord by a C-2 segmental-type vertebral artery (VA) that was successfully treated with microvascular decompression. " 10/01/2014 - "Microvascular decompression of a C-2 segmental-type vertebral artery producing trigeminal hypesthesia."
5.	Analgesia 09/01/2009 - "Secondary outcome measures were the degree of improvement in leg weakness, paraesthesia, numbness, walking distance and use of analgesia reported by the patients. " 04/28/2013 - "Physical examination revealed adipose elements superficial hypesthesia below the T5 level and analgesia below the T6 level. " 07/01/2012 - "Analgesia was tested by an Electric Pulp Tester (EPT) and the cutting of a standardized cavity, which was terminated when participants reported sensitivity, and Visual Analogue Scale (VAS) and numbness were recorded. " 01/01/2012 - "This may cause increased extremity numbness, but will provide greater analgesia, reduce supplemental opioid consumption, improve sleep quality and patient satisfaction. " 01/01/2005 - "We found significant correlations of analgesia with SASS ratings of numbness and soreness, but not with ratings of stabbing, throbbing, tingling, burning, heaviness, fullness, or aching. "