Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing α-synuclein and immune activation of Parkinson's disease.

Abstract

The most critical problem in the treatment of neurodegenerative diseases is brain neuronal protection, which can be overcome by clearing pathological substances and regulating the immune environment. In the above treatment strategies, the traditional poor drug delivery problem is inevitable. Here, we show an engineering core-shell hybrid system named rabies virus glycoprotein (RVG) peptide-modified exosome (EXO) curcumin/phenylboronic acid-poly(2-(dimethylamino)ethyl acrylate) nanoparticle/small interfering RNA targeting SNCA (REXO-C/ANP/S). It is a nanoscavenger for clearing α-synuclein aggregates and reducing their cytotoxicity in Parkinson's disease neurons. The motor behavior of Parkinson's disease mice is substantially improved after REXO-C/ANP/S treatment. In particular, we demonstrate that REXO-C/ANP/S is also a nanoscavenger for clearing immune activation due to its natural immature dendritic cell EXO coating. Our findings show that REXO-C/ANP/S may serve as a platform for neurodegenerative diseases treatment.

• Authors: Linying Liu, Yan Li, Huan Peng, Ruiyuan Liu, Weihong Ji, Zhuyan Shi, Jie Shen, Guanghui Ma, Xin Zhang
• Journal: Science advances (Sci Adv) Vol. 6 Issue 50 (12 2020) ISSN: 2375-2548 [Electronic] United States
• PMID: 33310840 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

Chemical References

• alpha-Synuclein
• Atrial Natriuretic Factor

Topics

• Animals
• Atrial Natriuretic Factor
• Exosomes (genetics)
• Mice
• Neurodegenerative Diseases
• Parkinson Disease (genetics, pathology)
• alpha-Synuclein (genetics)