HLA association with the susceptibility to anti-synthetase syndrome.

Abstract

OBJECTIVE:

To investigate the human leukocyte antigen (HLA) association with anti-synthetase syndrome (ASSD).

METHODS:

We conducted the largest immunogenetic HLA-DRB1 and HLA-B study to date in a homogeneous cohort of 168 Caucasian patients with ASSD and 486 ethnically matched healthy controls by sequencing-based-typing.

RESULTS:

A statistically significant increase of HLA-DRB1*03:01 and HLA-B*08:01 alleles in patients with ASSD compared to healthy controls was disclosed (26.2% versus 12.2%, P=1.56E-09, odds ratio-OR [95% confidence interval-CI]=2.54 [1.84-3.50] and 21.4% versus 5.5%, P=18.95E-18, OR [95% CI]=4.73 [3.18-7.05]; respectively). Additionally, HLA-DRB1*07:01 allele was significantly decreased in patients with ASSD compared to controls (9.2% versus 17.5%, P=0.0003, OR [95% CI]=0.48 [0.31-0.72]). Moreover, a statistically significant increase of HLA-DRB1*03:01 allele in anti-Jo-1 positive compared to anti-Jo-1 negative patients with ASSD was observed (31.8% versus 15.5%, P=0.001, OR [95% CI]=2.54 [1.39-4.81]). Similar findings were observed when HLA carrier frequencies were assessed. The HLA-DRB1*03:01 association with anti-Jo-1 was unrelated to smoking history. No HLA differences in patients with ASSD stratified according to the presence/absence of the most representative non-anti-Jo-1 anti-synthetase autoantibodies (anti-PL-12 and anti-PL-7), arthritis, myositis or interstitial lung disease were observed.

CONCLUSIONS:

Our results support the association of the HLA complex with the susceptibility to ASSD.

• Authors: Sara Remuzgo-Martínez, Belén Atienza-Mateo, J Gonzalo Ocejo-Vinyals, Verónica Pulito-Cueto, Diana Prieto-Peña, Fernanda Genre, Ana Marquez, Javier Llorca, Víctor M Mora Cuesta, David Iturbe Fernández, Laura Riesco, Norberto Ortego-Centeno, Nair Pérez Gómez, Antonio Mera, Julia Martínez-Barrio, Francisco Javier López-Longo, Leticia Lera-Gómez, Clara Moriano, Elvira Díez, Eva Tomero, Jaime Calvo-Alén, Fredeswinda Romero-Bueno, Olga Sanchez-Pernaute, Laura Nuño, Gema Bonilla, Ignacio Grafia, Sergio Prieto-González, Javier Narvaez, Ernesto Trallero-Araguas, Albert Selva-O'Callaghan, Oreste Gualillo, Javier Martín, Lorenzo Cavagna, Santos Castañeda, José M Cifrian, Elisabetta A Renzoni, Raquel López-Mejías, Miguel A González-Gay
• Journal: Joint bone spine (Joint Bone Spine) Vol. 88 Issue 3 Pg. 105115 (05 2021) ISSN: 1778-7254 [Electronic] France
• PMID: 33301929 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Société française de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.

Chemical References

• Antibodies, Antinuclear
• Autoantibodies
• HLA Antigens
• HLA-DRB1 Chains
• Ligases

Topics

• Alleles
• Antibodies, Antinuclear
• Autoantibodies
• Case-Control Studies
• Genetic Predisposition to Disease
• HLA Antigens
• HLA-DRB1 Chains (genetics)
• Humans
• Ligases
• Myositis (genetics)