Abstract |
The present study was investigated to verify anti-inflammatory and immune regulation effect of Zaluzanin D on LPS-induced macrophages and acute lung injury. NR8383 macrophages were pre-treated with Zaluzanin D and stimulated by LPS. Zaluzanin D reduced the production of nitric oxide in NR8383 macrophages and decreased the secretions of inflammatory cytokines. In addition, intravenous of Zaluzanin D to LPS-induced rats reduced the infiltrations of macrophages into BALF and the histological inflammatory changes in lung tissues. Furthermore, Z.D inhibited lipid peroxidation and effectively recruit the anti-oxidative defense system, regulated the levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 in the lungs by inhibitory expression of nuclear factor-kappa B pathway. These findings suggested that Zaluzanin D attenuated pulmonary inflammatory responses by inhibiting the expression of diverse inflammatory mediators in vitro and in vivo.
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Authors | Yongjie Wang, Jiaozhen Zhang, Xinli Gao, Qiang Li, Deqing Sun |
Journal | International immunopharmacology
(Int Immunopharmacol)
Vol. 90
Pg. 107130
(Jan 2021)
ISSN: 1878-1705 [Electronic] Netherlands |
PMID | 33218937
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Elsevier B.V. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Antioxidants
- Cytokines
- Inflammation Mediators
- NF-kappa B
- Sesquiterpenes
- zaluzanin-D
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Topics |
- Achillea
(chemistry)
- Active Transport, Cell Nucleus
- Animals
- Anti-Inflammatory Agents
(isolation & purification, pharmacology)
- Antioxidants
(isolation & purification, pharmacology)
- Cell Line
- Cytokines
(metabolism)
- Disease Models, Animal
- Inflammation Mediators
(metabolism)
- Lipid Peroxidation
(drug effects)
- Macrophages
(drug effects, immunology, metabolism)
- Male
- NF-kappa B
(metabolism)
- Pneumonia
(immunology, metabolism, prevention & control)
- Rats, Sprague-Dawley
- Sesquiterpenes
(isolation & purification, pharmacology)
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