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In vitro and in vivo anti-inflammatory effect of Zaluzanin D isolated from Achillea acuminate.

Abstract
The present study was investigated to verify anti-inflammatory and immune regulation effect of Zaluzanin D on LPS-induced macrophages and acute lung injury. NR8383 macrophages were pre-treated with Zaluzanin D and stimulated by LPS. Zaluzanin D reduced the production of nitric oxide in NR8383 macrophages and decreased the secretions of inflammatory cytokines. In addition, intravenous of Zaluzanin D to LPS-induced rats reduced the infiltrations of macrophages into BALF and the histological inflammatory changes in lung tissues. Furthermore, Z.D inhibited lipid peroxidation and effectively recruit the anti-oxidative defense system, regulated the levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 in the lungs by inhibitory expression of nuclear factor-kappa B pathway. These findings suggested that Zaluzanin D attenuated pulmonary inflammatory responses by inhibiting the expression of diverse inflammatory mediators in vitro and in vivo.
AuthorsYongjie Wang, Jiaozhen Zhang, Xinli Gao, Qiang Li, Deqing Sun
JournalInternational immunopharmacology (Int Immunopharmacol) Vol. 90 Pg. 107130 (Jan 2021) ISSN: 1878-1705 [Electronic] Netherlands
PMID33218937 (Publication Type: Journal Article)
CopyrightCopyright © 2020 Elsevier B.V. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Antioxidants
  • Cytokines
  • Inflammation Mediators
  • NF-kappa B
  • Sesquiterpenes
  • zaluzanin-D
Topics
  • Achillea (chemistry)
  • Active Transport, Cell Nucleus
  • Animals
  • Anti-Inflammatory Agents (isolation & purification, pharmacology)
  • Antioxidants (isolation & purification, pharmacology)
  • Cell Line
  • Cytokines (metabolism)
  • Disease Models, Animal
  • Inflammation Mediators (metabolism)
  • Lipid Peroxidation (drug effects)
  • Macrophages (drug effects, immunology, metabolism)
  • Male
  • NF-kappa B (metabolism)
  • Pneumonia (immunology, metabolism, prevention & control)
  • Rats, Sprague-Dawley
  • Sesquiterpenes (isolation & purification, pharmacology)

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