Coronary artery bypass grafting (CABG) done on-pump may cause a significant blood loss. Low
fibrinogen is associated with perioperative
bleeding. The influence of
cardiopulmonary bypass on
fibrin clot properties is poorly investigated. We studied 55 patients with isolated
coronary artery disease on
aspirin undergoing on-pump CABG with
tranexamic acid.
Fibrinogen levels, fibrinolytic capacity expressed as clot lysis time (CLT),
thrombin generation potential and platelet count were assessed before and after the surgery (prior to admission to the intensive care unit). A postoperative drop in haemoglobin (-30% from baseline), haematocrit (-31% from baseline) and platelet count (-42% from baseline) was observed (all, P < 0.0001). Postoperative
fibrinogen level was lower by 57%, compared with preoperative value (1.5 [1.3-1.8] vs. 3.5 [2.8-3.9] g/l, P < 0.0001). Postoperative CLT was longer by 48 min, compared with preoperative (182 [170-218] vs. 134 [122-165] min, P < 0.0001).
Thrombin generation was impaired postoperatively: both lag time and time to peak
thrombin were prolonged by 44 and 45%, respectively, whereas endogenous
thrombin potential and peak
thrombin generation decreased by 45 and 78%, respectively (all P < 0.0001). Median postoperative drainage at 12 h was 400 [290-570] ml. Predictors of blood loss at 12 h identified in multivariable linear regression model adjusted for sex and preoperative
fibrinogen level were: BMI (b = -23.4, P = 0.048) and postoperative CLT (b = -2.4, P = 0.042). Despite decreased
fibrinogen levels after on-pump CABG with
tranexamic acid,
fibrin clot susceptibility to lysis is impaired, as reflected by prolonged CLT. Postoperative CLT is associated with mediastinal drainage at 12 h.