Parsley (Petroselinum crispum L.) has been used as food, spices and in folkloric medicine. Several scientific researches have been focalized on anti-inflammatory, anti-proliferative,
antioxidant and other pharmacological activities of parsley. The aim of the present study was to evaluate the
phytochemical composition,
antioxidant and anticancer activity of P. crispum L aqueous and
methanol extracts against Human
glioblastoma cells U87MG. Adhesion assay was realized on different
protein matrices (
fibrinogen,
fibronectin and poly-
L-lysine) and the anti-proliferative effect was performed. Compared to aqueous extract, the
methanol extract presented an important level of
phenol contents. Five phenolic compounds were found using HPLC-DAD with
quinic acid as the most abounded followed by
gallic acid,
acacetin,
protocatechuic acid and
Cirsilineol with 120753.07 ± 27450; 190 ± 25; 53.83 ± 10; 13.7 ± 2.5 and 2 ± 0.3 µg/mL respectively.The DPPH,
ABTS+,
OH radical,
Iron (II) chelation and FRAP assays exhibited that
methanol extract show a modulate
antioxidant activity. The
methanol extract shows the highest ability to inhibit cell adhesion to different
protein matrices. In addition, it was found as a potential anti-proliferative. These results suggest for the first time that P. crispum
methanol extract presents anti-adhesion and anti-proliferative proprieties.