acacetin

01/01/2023 - "Echocardiography, histopathological methods, and Western blotting techniques were used to evaluate the anti-fibrosis effects in spontaneous hypertensive rat (SHR) which were daily intragastrically administrated with acacetin (10 mg/kg and 20 mg/kg) for 6 weeks. "
01/01/2023 - "Acacetin Alleviates Cardiac Fibrosis via TGF-β1/Smad and AKT/mTOR Signal Pathways in Spontaneous Hypertensive Rats."
09/01/2020 - "We found that acacetin did have an improvement on endothelial dysfunction and fibrosis. "
01/01/2023 - "The aim of this study was to investigate the potential molecular mechanisms underlying the protective role of acacetin on hypertension-induced cardiac fibrosis. "
01/01/2023 - "Angiotensin II (Ang II) was used to induce cellular fibrosis in human cardiac fibroblasts (HCFs) in the absence and presence of acacetin treatment for 48 h. "

12/01/2022 - "Overall, our findings suggest that acacetin can act as a protective barrier against CuSO4-induced inflammation in an in-vivo zebrafish larval model."
04/23/2022 - "Acacetin may protect against hepatic steatosis by modulating inflammation and AMPK expression."
01/01/2021 - "Furthermore, Acacetin could modulate gastrointestinal inflammation and apoptosis. "
01/01/2020 - "However, the effects of acacetin on intestinal inflammation remain unclear. "
01/01/2020 - "Protective effect of acacetin in human periodontal ligament cells via regulation of autophagy and inflammation."

01/01/2023 - "The in vivo antitumor efficacy of acacetin was assessed in a subcutaneous xenotransplanted tumor model. "
10/30/2021 - "Acacetin is a potent molecule extracted from plants with anti-cancer and anti-inflammatory bioactivities. "
10/14/2021 - "These results suggest that acacetin, as a STAT3 inhibitor, could be a possible drug candidate for targeting STAT3 for the treatment of cancer in humans."
10/14/2021 - "We also found that acacetin inhibits tumor growth in xenografted nude mice. "
02/01/2020 - "Acacetin, a bioflavanoid, contains anti-inflammatory and anti-cancer activities as shown in different experimental models. "

02/01/2014 - "In this study, we investigated whether acacetin induces apoptosis in the human prostate cancer cell line, DU145. "
02/01/2014 - "We further evaluated the effects of acacetin on prostate cancer using mice subcutaneously injected with DU145 prostate cancer cells. "
02/01/2014 - "Acacetin (5,7-dihydroxy-4'-methoxyflavone) exhibits in vitro and in vivo anticancer activity through the suppression of NF-κB/Akt signaling in prostate cancer cells."
01/01/2010 - "The effect of acacetin on antimetastasis in human prostate cancer DU-145 cells was investigated. "
10/14/2021 - "Acacetin, a flavone present in various plants, inhibits constitutive and inducible STAT3 activation in STAT3-activated DU145 prostate cancer cells. "

01/01/2013 - "The use- and rate-dependent blocking of hKv4.3 by acacetin is likely beneficial for managing atrial fibrillation."
12/01/2011 - "The use- and rate-dependent blocking of hKv1.5 by acacetin is beneficial for anti-atrial fibrillation."
12/01/2023 - "Acacetin is reported as a potential drug candidate for the treatment of atrial fibrillation. "
10/01/2016 - "We previously reported that duodenal administration of the natural flavone acacetin can effectively prevent the induction of experimental atrial fibrillation (AF) in canines; however, it may not be used intravenously to terminate AF due to its poor water-solubility. "
10/01/2016 - "Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs."