Serum uromodulin is inversely associated with arterial hypertension and the vasoconstrictive prohormone CT-proET-1 in the population-based KORA F4 study.

Abstract

OBJECTIVES:

Uromodulin has been associated with arterial hypertension in genome-wide association studies, but data from clinical and preclinical studies are inconsistent. We here analyzed the association of serum uromodulin (sUmod) with arterial hypertension and vasoactive hormones in a population-based study.

METHODS:

In 1108 participants of the KORA F4 study aged 62-81 years, sUmod was measured and the association of sUmod with arterial hypertension was assessed using logistic regression models. The associations of sUmod with renin and aldosterone and with the vasoconstrictive prohormone C-terminal pro-endothelin-1 (CT-proET-1) were analyzed in 1079 participants and in 618 participants, respectively, using linear regression models.

RESULTS:

After multivariable adjustment including sex, age, eGFR, BMI, fasting glucose, current smoking, previous stroke and myocardial infarction, sUmod was inversely associated with arterial hypertension (OR 0.78; 95% CI 0.68-0.91; p = 0.001). SUmod was not significantly associated with renin and aldosterone after adjustment for sex, age and eGFR. However, sUmod was inversely associated with CT-proET-1 (β -0.19 ± 0.04; p < 0.001) after adjustment for sex, age, eGFR, BMI, arterial hypertension, fasting glucose, current smoking, previous stroke and myocardial infarction. The association with CT-proET-1 was stronger in participants with hypertension (β -0.22 ± 0.04) than in normotensive participants (β -0.13 ± 0.06; p for interaction hypertension = 0.003 in the model adjusted for hypertension).

CONCLUSIONS:

SUmod was inversely associated with arterial hypertension and the vasoconstrictive prohormone CT-proET-1, suggesting direct or indirect effects of sUmod on blood pressure regulation.

• Authors: Cornelia Then, Barbara Thorand, Holger L Then, Christa Meisinger, Margit Heier, Annette Peters, Wolfgang Koenig, Wolfgang Rathmann, Martin Bidlingmaier, Andreas Lechner, Martin Reincke, Jürgen E Scherberich, Jochen Seissler
• Journal: PloS one (PLoS One) Vol. 15 Issue 8 Pg. e0237364 ( 2020) ISSN: 1932-6203 [Electronic] United States
• PMID: 32764816 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• C-terminal proendothelin-1
• Endothelin-1
• Peptide Fragments
• Uromodulin
• Aldosterone
• Renin

Topics

• Aged
• Aldosterone (blood)
• Endothelin-1 (blood)
• Female
• Humans
• Hypertension (blood, epidemiology)
• Male
• Peptide Fragments (blood)
• Renin (blood)
• Uromodulin (blood)