Abstract | AIMS: MATERIAL AND METHODS: A thorough search strategy was applied to identify published research trials in PubMed, Scopus, Medline, and EMBASE from Dec 1, 2019, to May 4, 2020, for studies reporting clinical outcomes of COVID-19 patients treated with immunotherapies along with other standard cares. KEY FINDINGS: From an initial screen of 80 identified studies, 24 studies provided clinical outcome data on the use of immunotherapies for the treatment of COVID-19 patients, including convalescent plasma therapy (33 patients), monoclonal antibodies (55 patients), interferon (31 patients), mesenchymal stem cell therapy (8 patient), and immunoglobulin (63 patients). Except for nine severe patients who died after treatment, most patients were recovered from COVID-19 with improved clinical symptoms and laboratory assessment. SIGNIFICANCE: Based on the available evidence, it seems that treatment with immunotherapy along with other standard cares could be an effective and safe approach to modulate the immune system and improvement of clinical outcomes.
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Authors | Amir Hossein Mansourabadi, Mona Sadeghalvad, Hamid-Reza Mohammadi-Motlagh, Nima Rezaei |
Journal | Life sciences
(Life Sci)
Vol. 258
Pg. 118185
(Oct 01 2020)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 32750438
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
Chemical References |
- Antibodies, Monoclonal
- Immunoglobulins, Intravenous
- Interferons
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Topics |
- Antibodies, Monoclonal
(therapeutic use)
- Betacoronavirus
(immunology)
- COVID-19
- Coronavirus Infections
(immunology, therapy)
- Humans
- Immunization, Passive
(methods)
- Immunoglobulins, Intravenous
(therapeutic use)
- Immunotherapy
(methods)
- Interferons
(therapeutic use)
- Mesenchymal Stem Cell Transplantation
- Pandemics
- Pneumonia, Viral
(immunology, therapy)
- SARS-CoV-2
- Treatment Outcome
- COVID-19 Serotherapy
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