Abstract | OBJECTIVES: METHODS: We analysed the prevalence and titres of serum aPL in 122 patients with COVID-19 and 157 with primary antiphospholipid syndrome (PAPS) and 91 with other autoimmune rheumatic diseases (oARD) for comparison. IgG/ IgM anticardiolipin (aCL) and IgG/ IgM anti-beta2glycoprotein I (β2GPI) were assayed using homemade ELISA, IgA aCL and anti-β2GPI by commercial ELISA kits and lupus anticoagulant (LAC) by multiple coagulation tests following updated international guidelines. RESULTS: Prevalence of IgG and IgM aCL and of IgG and IgM anti-β2GPI across COVID-19 patients were 13.4%, 2.7%, 6.3% and 7.1%, being significantly lower than in PAPS (p<0.0001 for all). Frequency of IgG aCL and IgM anti-β2GPI was comparable to oARD (13.4% vs. 13.2% and 7.1% vs. 11%, respectively), while IgG anti-β2GPI and IgM aCL were lower (p<0.01). IgA aCL and IgA anti-β2GPI were retrieved in 1.7% and 3.3% of COVID-19 patients, respectively. Positive LAC was observed in 22.2% COVID-19 vs. 54.1% of PAPS (p<0.0001) and 14.6% of oARD (p=0.21). Venous or arterial thromboses occurred in 18/46 (39.1%) COVID-19 patients and were not associated with positive aPL (p=0.09). CONCLUSIONS:
Thrombosis is a frequent manifestation during COVID-19 infection. However, prevalence and titres of aPL antibodies or LAC were neither consistently increased nor associated with thrombosis when measured at a single timepoint, therefore not representing a suitable screening tool in the acute stage of disease.
|
Authors | Mariele Gatto, Carlo Perricone, Marta Tonello, Onelia Bistoni, Anna Maria Cattelan, Roberto Bursi, Giacomo Cafaro, Edoardo De Robertis, Antonella Mencacci, Silvia Bozza, Andrea Vianello, Luca Iaccarino, Roberto Gerli, Andrea Doria, Elena Bartoloni |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
2020 Jul-Aug
Vol. 38
Issue 4
Pg. 754-759
ISSN: 0392-856X [Print] Italy |
PMID | 32723434
(Publication Type: Journal Article, Multicenter Study)
|
Chemical References |
- Antibodies, Anticardiolipin
- Antibodies, Antiphospholipid
- Immunoglobulin G
- Immunoglobulin M
- beta 2-Glycoprotein I
|
Topics |
- Antibodies, Anticardiolipin
(blood)
- Antibodies, Antiphospholipid
(blood)
- Antiphospholipid Syndrome
(blood)
- Betacoronavirus
- COVID-19
- Coronavirus Infections
(blood, immunology)
- Humans
- Immunoglobulin G
(blood)
- Immunoglobulin M
(blood)
- Pandemics
- Pneumonia, Viral
(blood, immunology)
- SARS-CoV-2
- Thrombosis
(complications, virology)
- beta 2-Glycoprotein I
(immunology)
|