Lupus Coagulation Inhibitor (Lupus Anticoagulant)

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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Networked: 1686 relevant articles (18 outcomes, 80 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Cervera, Ricard: 14 articles (02/2015 - 12/2002)
2.	Eichinger, Sabine: 13 articles (01/2014 - 11/2002)
3.	Pengo, V: 11 articles (07/2015 - 01/2008)
4.	Kyrle, Paul A: 11 articles (01/2014 - 11/2002)
5.	Ruffatti, A: 9 articles (07/2015 - 01/2008)
6.	Atsumi, Tatsuya: 8 articles (11/2015 - 02/2002)
7.	Quehenberger, Peter: 8 articles (05/2015 - 01/2002)
8.	Espinosa, Gerard: 8 articles (02/2015 - 12/2002)
9.	Kyrle, P A: 8 articles (05/2014 - 08/2000)
10.	Khamashta, M A: 8 articles (01/2006 - 03/2000)

Related Diseases

1.	Thrombosis (Thrombus) 12/01/1998 - "Patients with a lupus anticoagulant (LAC) may present with thrombosis, and abnormal coagulation studies. " 04/01/1992 - "The study shows a strong association between lupus anticoagulant and thrombosis when a very sensitive test such as the dilute aPTT is used. " 12/01/1987 - "Lupus anticoagulant causes a prolongation of certain laboratory coagulation studies yet it is associated in vivo with a history of systemic intravascular thromboses. " 01/01/1987 - "The present study confirms observations that SLE patients with the lupus anticoagulant have an increased risk of thrombosis." 02/01/1980 - "This study suggests that patients with the lupus anticoagulant may be at increased risk of thrombosis."
2.	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 01/01/2015 - "Variability in the international normalised ratio (INR) in patients with antiphospholipid syndrome and positive lupus anticoagulant: should the INR targets be higher?" 05/01/2013 - "The role of lupus anticoagulant and triple marker positivity as risk factors for rethrombosis in patients with primary antiphospholipid syndrome." 02/01/2013 - "Phospholipid-dependent coagulation tests for lupus anticoagulant (LA) are considered an important step for the diagnosis of anti-phospholipid syndrome; however, LA laboratory detection is difficult because of many variables. " 01/01/2013 - "Investigations revealed a positive lupus anticoagulant and she was given a presumptive diagnosis of catastrophic antiphospholipid syndrome (CAPS). " 06/01/2011 - "The latter more often correlate with clinical manifestations of antiphospholipid syndrome and with lupus anticoagulant activity. "
3.	Lymphoma (Lymphomas) 08/01/1991 - "Visual scotomata resulting from lupus anticoagulant in a patient with lymphoma in remission." 06/01/2015 - "We present a case concerning a patient with splenic marginal zone lymphoma (SMZL) and isolated prolonged activated partial thromboplastin time (aPTT) caused by lupus anticoagulant. " 10/01/2011 - "It is suggested that a search for lupus anticoagulant should be done in all patients with lymphoma, because a diagnosis of lupus anticoagulant may influence the management of lymphomas in some patients." 12/01/1991 - "Lupus anticoagulant associated with primary malignant lymphoplasmacytic lymphoma of the spleen: a report of four patients." 10/01/2011 - "The lupus anticoagulant could be eliminated by lymphoma treatment (chemoimmunotherapy or splenectomy) in more than one-third of patients. "
4.	Hypertension (High Blood Pressure) 09/01/2005 - "A significant difference was seen for 4 factors: past history of thrombotic event (PHTE; odds ratio: 101.93; 95% confidence interval: 12.29-845.22; p < 0.0001), hypertension (odds ratio: 8.87; 95% CI: 2.58-30.53; p < 0.001), DM (odds ratio: 5.42; 95% CI: 1.44-20.46; p < 0.05), and lupus anticoagulant (LAC; odds ratio: 47.41; 95% CI: 5.88-382.03, p < 0.0001) as aPLs, when the incidence of these risk factors was compared between patients with and without new thrombotic events. " 06/01/2013 - "Lupus anticoagulant and hypertension were identified by Cox regression analysis as independent risk factors for thrombosis [hazard ratio (HR) 4·1, 95% CI 1·4-11·9, P = 0·009 and HR 5·6, 95% CI 1·9-15·8, P = 0·001, respectively]. " 04/01/2013 - "Fifty-one elderly patients with RVO and 51 healthy individuals matched for age and sex were evaluated for systemic risk factors (smoking, diabetes, dyslipidemia, arterial hypertension) and coagulation defects (lupus anticoagulant, natural inhibitors of coagulation). " 06/01/2011 - "Hypertension and lupus anticoagulant (LA) were significantly predictive of thrombosis (both at p<0.05) and thromboprophylaxis was significantly protective during high-risk periods (p<0.05) according to univariate analysis. " 05/01/2004 - "Thus, fetal loss is common, particularly in patients with a lupus anticoagulant, renal failure, or arterial hypertension. "
5.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 11/01/1992 - "Lupus anticoagulant in systemic lupus erythematosus: a clinical and renal pathological study." 09/01/2012 - "The second patient is an 18-year-old girl, diagnosed 2 years previously with systemic lupus erythematosus and lupus anticoagulant, who started taking an OC 4 months before the onset of symptoms. " 08/01/2010 - "A 45-year-old Chinese woman with active systemic lupus erythematosus, lupus anticoagulant positive, was admitted to our hospital. " 02/01/2008 - "Two groups of consecutive patients with PAPS and systemic lupus erythematosus (SLE): 32 patients with lupus anticoagulant (LAC), 32 patients without LAC, and 40 healthy controls were included. " 05/01/2001 - "Diffuse muscular haemorrhage as presenting sign of juvenile systemic lupus erythematosus and lupus anticoagulant hypoprothrombinaemia syndrome."

Related Drugs and Biologics

1.	Anticardiolipin Antibodies
2.	Antibodies
3.	Autoantibodies
4.	Antiphospholipid Antibodies
5.	Antinuclear Antibodies
6.	Heparin (Liquaemin)
7.	Aspirin (Acetylsalicylic Acid)
8.	Anticoagulants
9.	anti-thyroglobulin
10.	Procainamide (Procan)

Related Therapies and Procedures

1.	Splenectomy
2.	Transplants (Transplant)
3.	Transplantation (Transplant Recipients)
4.	Renal Dialysis (Hemodialysis)
5.	Homologous Transplantation (Allograft)