With the extensive application of
radiotherapy in various
cancers, its side effects in tissues adjacent to
cancers are garnering much attention. Intestines are sensitive to irradiation due to its rapid proliferation, and irradiation-induced enteric
inflammation is common in patients with pelvic peritoneal
tumors.
Sirt1, class III
protein deacetylase, could lead to transcriptional repression of various
inflammation-associated genes, and our previous study has proved its relationship with
interleukin (IL)-1β. Here we show that
resveratrol, the activator of
Sirt1, could alleviate the bowel
inflammation induced by irradiation and the expression of
Sirt1 is consistent with the
inflammation level. We further identified in vivo that
Sirt1 repress the expression of IL-1β by the repression of NLR Family, Pyrin Domain Containing
protein 3 (NLRP3) expression. In conclusion, this study confirms
resveratrol acts against radiation-induced
inflammatory bowel disease via NLRP-3
inflammasome repression in mice and supports
Sirt1 as a potential
biomarker and
therapy target in intestinal radiation protection.