Abstract | OBJECTIVE: METHODS: A cross-sectional study was conducted on 280 patients with SLE [46.9 (12.85) years]. Med Diet adherence was assessed through a 14-item questionnaire on food consumption frequency and habits (total score from 0 to 14 points; higher score is greater adherence to the Med Diet). CRP, homocysteine, SLEDAI-2K (SLE disease activity), and SLICC/ACR and SDI (damage accrual) were measured. Obesity, diabetes mellitus, hypertension and blood lipids, among others, were considered cardiovascular disease risk factors. RESULTS: Greater adherence to the Med Diet was significantly associated with better anthropometric profiles, fewer cardiovascular disease risk factors, and lower disease activity and damage accrual scores (P ≤ 0.001 for SLEDAI and SDI). An inverse relationship between the Med Diet score and SLEDAI (P ≥ 0.001; β = -0.380), SDI (P ≤ 0.001; β = -0.740) and hsCRP (P = 0.039; β = -0.055) was observed. The odds ratio for having active SLE (SLEDAI ≥5) or the presence of damage (SDI ≥1) was lower among patients whose Med Diet score was higher (P ≤ 0.001). Finally, greater consumption of Med Diet foods ( olive oil, fruits, vegetables, fish, etc.) and abstaining from red meat and meat products, sugars and pastries was associated with less SLE clinical activity and damage. CONCLUSION: Greater adherence to the Med Diet seems to exert a beneficial effect on disease activity and cardiovascular risk in SLE patients. To confirm these findings, further longitudinal studies would be of interest.
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Authors | Gabriela Pocovi-Gerardino, María Correa-Rodríguez, José-Luis Callejas-Rubio, Raquel Ríos-Fernández, María Martín-Amada, María-Gracia Cruz-Caparros, Blanca Rueda-Medina, Norberto Ortego-Centeno |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 60
Issue 1
Pg. 160-169
(01 05 2021)
ISSN: 1462-0332 [Electronic] England |
PMID | 32594173
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: [email protected]. |
Chemical References |
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Topics |
- Adult
- Ankle Brachial Index
- Cardiovascular Diseases
(prevention & control)
- Cross-Sectional Studies
- Diabetes Mellitus
(diet therapy)
- Diet, Mediterranean
- Female
- Heart Disease Risk Factors
- Humans
- Hypertension
(diet therapy)
- Lipids
(blood)
- Lupus Erythematosus, Systemic
(blood, diet therapy)
- Male
- Middle Aged
- Nutritional Physiological Phenomena
- Obesity
(diet therapy)
- Odds Ratio
- Patient Compliance
(statistics & numerical data)
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