Abstract |
Using broad-spectrum antibiotics for microbial infection may cause flora disequilibrium, drug-resistance, etc., seriously threatening human health. Here, we design a human defensin-6 mimic peptide (HDMP) that inhibits bacterial invasion in vivo through mimicking the mechanisms of human defensin-6 with high efficiency and precision. The HDMP with ligand and self-assembling peptide sequence recognizes bacteria through ligand-receptor interactions and subsequently traps bacteria by an in situ adaptive self-assembly process and resulting nanofibrous networks; these trapped bacteria are unable to invade host cells. In four animal infection models, the infection rate was markedly decreased. Notably, administration of HDMP (5 mg/kg) nanoparticles increased the survival rate of mice with methicillin-resistant S. aureus bacteremia by as much as 100%, even more than that of vancomycin treatment (5 mg/kg, 83.3%)-treated group, the golden standard of antibiotics. This biomimetic peptide shows great potential as a precise and highly efficient antimicrobial agent.
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Authors | Yu Fan, Xiang-Dan Li, Ping-Ping He, Xiao-Xue Hu, Kuo Zhang, Jia-Qi Fan, Pei-Pei Yang, Hao-Yan Zheng, Wen Tian, Zi-Ming Chen, Lei Ji, Hao Wang, Lei Wang |
Journal | Science advances
(Sci Adv)
Vol. 6
Issue 19
Pg. eaaz4767
(05 2020)
ISSN: 2375-2548 [Electronic] United States |
PMID | 32494712
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). |
Chemical References |
- Anti-Bacterial Agents
- Defensins
- Ligands
- Vancomycin
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Topics |
- Animals
- Anti-Bacterial Agents
(pharmacology)
- Bacteria
- Biomimetics
- Defensins
(pharmacology)
- Humans
- Ligands
- Methicillin-Resistant Staphylococcus aureus
- Mice
- Vancomycin
(pharmacology)
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