Abstract | BACKGROUND: AIM: to assess plasma Hcy status and HHcy main determinants in patients with AP. MATERIALS AND METHODS: RESULTS: Symptomatic AP patients had significantly higher urinary ALA and PBG levels, plasma Hcy, HHcy prevalence and Hcy/Cys ratio when compared to asymptomatic carriers of AP. Even though no significant correlation was observed between ALA/PBG urinary levels and serum Hcy levels, patients with higher levels of ALA and PBG had significantly higher levels of Hcy, a higher prevalence of moderate-to severe HHcy and serum PLP levels below the 25th percentile of a reference assessment with 300 healthy Italian subjects(<45nmol/L). CONCLUSIONS: Most patients with symptomatic AP present HHcy resulting from alterations in sulphur amino acid metabolism. HHcy may represent an indirect marker of ALAS1 induction and its prevalence may be suggestive of a role of HHcy in the pathogenesis and/or comorbidities of AP.
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Authors | Paolo Ventura, Elena Corradini, Elena Di Pierro, Stefano Marchini, Matteo Marcacci, Chiara Cuoghi, Elena Buzzetti, Antonello Pietrangelo |
Journal | European journal of internal medicine
(Eur J Intern Med)
Vol. 79
Pg. 101-107
(09 2020)
ISSN: 1879-0828 [Electronic] Netherlands |
PMID | 32487371
(Publication Type: Journal Article)
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Copyright | Copyright © 2020. Published by Elsevier B.V. |
Chemical References |
- Homocysteine
- Cystathionine beta-Synthase
- Vitamin B 12
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Topics |
- Cystathionine beta-Synthase
- Homocysteine
- Humans
- Hyperhomocysteinemia
(epidemiology)
- Porphyria, Acute Intermittent
(complications, epidemiology)
- Vitamin B 12
|