Study on the correlation between anti-ribosomal P protein antibody and systemic lupus erythematosus.

Abstract

The aims of this study were to compare diagnostic value of anti-ribosomal P protein antibody (anti-P), anti-Smith antibody (anti-Sm), anti-double-stranded DNA antibody (anti-dsDNA), anti-nucleosome antibody (ANuA), and anti-histone antibody (AHA) for systemic lupus erythematosus (SLE) as well as explore the correlation between anti-P and SLE.A retrospective study was performed with 487 SLE patients, 235 non-SLE rheumatic diseases, and 124 healthy subjects from January 2015 to December 2018. Clinical manifestations, laboratory results and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)-2000 scores were analyzed between anti-P/+/ and anti-P/-/ patients. SPSS19.0 statistical software was used for data analysis.The sensitivities of anti-P, anti-Sm, anti-dsDNA, ANuA, and AHA in SLE were 31.6%, 20.7%, 45.0%, 27.9%, and 14.6%, and the specificities were 99.2%, 99.4%, 98.9%, 98.3%, and 96.7%, respectively. Only 27.9% of SLE had a single positive anti-P while the other 4 antibodies were all negative. There were significant differences in the age of onset, skin erythema, urinary protein, creatinine and serum IgG, IgM, C3, C4 between anti-P/+/ and anti-P/-/ patients (P < .05). When anti-Sjogren syndrome A antibody, anti-P were positive and anti-dsDNA was negative, the incidence of skin erythema was the highest (35.1%). Compared with anti-P/-/ patients, anti-P/+/ patients had higher SLEDAI scores (P < .001).Anti-P, anti-Sm, anti-dsDNA, ANuA, and AHA have high specificity but poor sensitivity in the diagnosis of SLE; combined detection can greatly improve the detection rate. Anti-P is more valuable in the diagnosis of SLE when other specific autoantibodies are negative. SLE patients with positive anti-P have an earlier onset age and are more prone to skin erythema, lupus nephritis as well as higher disease activity.

• Authors: Yanping Wang, Peng Luo, Ting Guo, Lin Zou, Jing Shi, Pu Chen
• Journal: Medicine (Medicine (Baltimore)) Vol. 99 Issue 20 Pg. e20192 (May 2020) ISSN: 1536-5964 [Electronic] United States
• PMID: 32443340 (Publication Type: Comparative Study, Journal Article, Observational Study)

Chemical References

• Antibodies, Antinuclear
• Autoantibodies
• Histones
• Membrane Transport Proteins
• Nucleosomes
• OCA2 protein, human
• Ribosomal Proteins
• SS-A antibodies
• DNA

Topics

• Adult
• Antibodies, Antinuclear (immunology)
• Autoantibodies (blood)
• DNA (antagonists & inhibitors, metabolism)
• Erythema (immunology, pathology)
• Female
• Histones (antagonists & inhibitors, metabolism)
• Humans
• Lupus Erythematosus, Systemic (diagnosis, immunology, pathology)
• Lupus Nephritis (immunology)
• Male
• Membrane Transport Proteins (immunology)
• Middle Aged
• Nucleosomes (metabolism)
• Retrospective Studies
• Rheumatic Diseases (immunology)
• Ribosomal Proteins (immunology)
• Sensitivity and Specificity
• Skin Diseases (epidemiology)