Abstract | BACKGROUND AND AIMS: METHODS: Igf2/Ldlr-/-Apob100/100 mice were fed a high-fat diet (HFD) for 8 weeks and then randomly allocated to receive HFD (n = 14), or HFD with added linagliptin (n = 15) for additional 12 weeks. Five mice fed a chow diet were studied as an additional control. At the end of the study, glucose tolerance, aortic and liver uptake of 18F-FDG, and histology were studied. RESULTS: CONCLUSIONS:
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Authors | Jenni Virta, Sanna Hellberg, Heidi Liljenbäck, Mia Ståhle, Johanna M U Silvola, Jenni Huusko, Mirva Söderström, Juhani Knuuti, Pirjo Nuutila, Seppo Ylä-Herttuala, Maria F Gomez, Anne Roivainen, Antti Saraste |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 305
Pg. 64-72
(07 2020)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 32386751
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 Elsevier B.V. All rights reserved. |
Chemical References |
- Dipeptidyl-Peptidase IV Inhibitors
- Fluorodeoxyglucose F18
- Linagliptin
- Dipeptidyl Peptidase 4
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Topics |
- Animals
- Atherosclerosis
(diagnostic imaging, drug therapy)
- Diabetes Mellitus, Type 2
(drug therapy)
- Dipeptidyl Peptidase 4
- Dipeptidyl-Peptidase IV Inhibitors
(therapeutic use)
- Fluorodeoxyglucose F18
- Inflammation
(drug therapy)
- Linagliptin
(therapeutic use)
- Mice
- Mice, Knockout
- Plaque, Atherosclerotic
- Positron-Emission Tomography
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