Biotin and glucose dual-targeting, ligand-modified liposomes promote breast tumor-specific drug delivery.

Abstract

Breast cancer is the second leading cause of cancer-related deaths in women. Ligand-modified liposomes are used for breast tumor-specific drug delivery to improve the efficacy and reduce the side effects of chemotherapy; however, only a few liposomes with high targeting efficiency have been developed because the mono-targeting, ligand-modified liposomes are generally unable to deliver an adequate therapeutic dose. In this study, we designed biotin-glucose branched ligand-modified, dual-targeting liposomes (Bio-Glu-Lip) and evaluated their potential as a targeted chemotherapy delivery system in vitro and in vivo. When compared with the non-targeting liposome (Lip), Bio-Lip, and Glu-Lip, Bio-Glu-Lip had the highest cell uptake in 4T1 cells (3.00-fold, 1.60-fold, and 1.95-fold higher, respectively) and in MCF-7 cells (2.63-fold, 1.63-fold, and 1.85-fold higher, respectively). The subsequent cytotoxicity and in vivo assays further supported the dual-targeting liposome is a promising drug delivery carrier for the treatment of breast cancer.

• Authors: Mengyi Huang, Yanchi Pu, Yao Peng, Qiuyi Fu, Li Guo, Yong Wu, Yongxiang Zheng
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 30 Issue 12 Pg. 127151 (06 15 2020) ISSN: 1464-3405 [Electronic] England
• PMID: 32317211 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents, Phytogenic
• Drug Carriers
• Ligands
• Liposomes
• Biotin
• Glucose
• Paclitaxel

Topics

• Animals
• Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
• Biotin (chemistry)
• Breast Neoplasms (drug therapy)
• Cell Line, Tumor
• Dose-Response Relationship, Drug
• Drug Carriers (chemical synthesis, chemistry)
• Drug Delivery Systems
• Female
• Glucose (chemistry)
• Humans
• Ligands
• Liposomes (chemistry)
• Mammary Neoplasms, Experimental (drug therapy)
• Mice
• Molecular Structure
• Paclitaxel (chemistry, pharmacology)
• Structure-Activity Relationship