Abstract | BACKGROUND AND AIMS: METHODS: In a sample of human males, structural and diffusion neuroimaging data were collected for 27 GHB users with ≥4 GHB-induced comas (GHB- Coma), 27 GHB users without GHB-induced comas (GHB-NoComa), and 27 polydrug users who never used GHB (No-GHB). The structural brain parameters were analyzed macroscopically using voxel-based morphometry and microscopically using tract-based spatial statistics (TBSS) and tractography. Impulsivity was assessed with the Barrat Impulsivity Scale. RESULTS: In comparison to the other two groups, the GHB- Coma group showed a higher fractional anisotropy in the body of the corpus callosum and a lower mean diffusivity in the forceps minor (i.e., whole-brain TBSS analysis). No macrostructural differences nor microstructural differences, as assessed with tractography, were observed. The GHB- Coma group also reported higher impulsivity, which was more strongly associated with white matter volume and fractional anisotropy in tracts involved in impulse control (post-hoc analysis). GHB use per se was associated neither with differences in brain structure nor with impulsivity. CONCLUSIONS: The results suggest that multiple GHB-induced comas, but not GHB use per se, are associated with microstructural alterations in white matter and with higher self-reported impulsivity, which in turn was associated with white matter tracts involved in impulse control.
|
Authors | Filipa Raposo Pereira, Minni T B McMaster, Arnt Schellekens, Nikki Polderman, Yvon D A T de Vries, Wim van den Brink, Guido A van Wingen |
Journal | Frontiers in psychiatry
(Front Psychiatry)
Vol. 11
Pg. 166
( 2020)
ISSN: 1664-0640 [Print] Switzerland |
PMID | 32300311
(Publication Type: Journal Article)
|
Copyright | Copyright © 2020 Raposo Pereira, McMaster, Schellekens, Polderman, de Vries, van den Brink and van Wingen. |