IL-9 and IL-9-producing cells in tumor immunity.

Abstract

Interleukin (IL)-9 belongs to the IL-2Rγc chain family and is a multifunctional cytokine that can regulate the function of many kinds of cells. It was originally identified as a growth factor of T cells and mast cells. In previous studies, IL-9 was mainly involved in the development of allergic diseases, autoimmune diseases and parasite infections. Recently, IL-9, as a double-edged sword in the development of cancers, has attracted extensive attention. Since T-helper 9 (Th9) cell-derived IL-9 was verified to play a powerful antitumor role in solid tumors, an increasing number of researchers have started to pay attention to the role of IL-9-skewed CD8+ T (Tc9) cells, mast cells and Vδ2 T cell-derived IL-9 in tumor immunity. Here, we review recent studies on IL-9 and several kinds of IL-9-producing cells in tumor immunity to provide useful insight into tumorigenesis and treatment. Video Abstract.

• Authors: Jie Wan, Yinqiu Wu, Xiaoyun Ji, Lan Huang, Wei Cai, Zhaoliang Su, Shengjun Wang, Huaxi Xu
• Journal: Cell communication and signaling : CCS (Cell Commun Signal) Vol. 18 Issue 1 Pg. 50 (03 30 2020) ISSN: 1478-811X [Electronic] England
• PMID: 32228589 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review, Video-Audio Media)

Chemical References

• IL9 protein, human
• Interleukin-9

Topics

• Animals
• CD8-Positive T-Lymphocytes (cytology, immunology)
• Humans
• Interleukin-9 (immunology)
• Mast Cells (cytology, immunology)
• Neoplasms (immunology)
• T-Lymphocytes, Helper-Inducer (cytology, immunology)