Abstract | BACKGROUND: METHODS: RESULTS: Up to 60.9% of the SNAPS and 93.5% of APS patients were detected by at least one non-criteria aPL. aPS/PT IgG had the highest Youden index in classifying APS and SNAPS from controls. aPS/PT IgG and aβ2GPI Domain 1 IgG seem to be the most significant risk factors for thrombotic events and pregnancy morbidity, respectively. aPS/PT IgG/ IgM and aβ2GPI-D1 IgG were detected in some SNAPS patients, while IgA isotypes of aCL/aβ2GPI tended to appear together with other biomarkers. The combined analysis showed enhanced diagnostic performance with the inclusion of non-criteria aPLs. CONCLUSIONS: Recognition of SNAPS patients is critical for clinical management and prevention of potential thrombotic and obstetric adverse events. The non-criteria antiphospholipid antibodies help to identify a considerable portion (60.9%) of these patients who otherwise may remain untreated and at clinical risk.
|
Authors | Tingting Liu, Jieyu Gu, Liyan Wan, Qiongyi Hu, Jialin Teng, Honglei Liu, Xiaobing Cheng, Junna Ye, Yutong Su, Yue Sun, Jinfeng Zhou, Gary L Norman, Xuefeng Wang, Chengde Yang, Hui Shi |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 22
Issue 1
Pg. 33
(02 21 2020)
ISSN: 1478-6362 [Electronic] England |
PMID | 32085759
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antibodies, Antiphospholipid
|
Topics |
- Adult
- Antibodies, Antiphospholipid
(blood, immunology)
- Antiphospholipid Syndrome
(blood, diagnosis, immunology)
- Asian People
- Case-Control Studies
- Cohort Studies
- Female
- Humans
- Male
- Middle Aged
|