Melatonin in Mitochondria: Mitigating Clear and Present Dangers.

Abstract

In cancer cells, glucose is primarily metabolized to pyruvate and then to lactate in the cytosol. By allowing the conversion of pyruvate to acetyl-CoA in mitochondria, melatonin reprograms glucose metabolism in cancer cells to a normal cell phenotype. Acetyl-CoA in the mitochondria also serves as a necessary co-factor for the rate-limiting enzyme in melatonin synthesis, thus ensuring melatonin production in mitochondria of normal cells.

• Authors: Russel J Reiter, Qiang Ma, Ramaswamy Sharma
• Journal: Physiology (Bethesda, Md.) (Physiology (Bethesda)) Vol. 35 Issue 2 Pg. 86-95 (03 01 2020) ISSN: 1548-9221 [Electronic] United States
• PMID: 32024428 (Publication Type: Journal Article, Review)

Chemical References

• Reactive Oxygen Species
• Acetyl Coenzyme A
• Glucose
• Melatonin

Topics

• Acetyl Coenzyme A (metabolism)
• Animals
• Glucose (metabolism)
• Humans
• Melatonin (metabolism)
• Mitochondria (metabolism)
• Neoplasms (metabolism, pathology)
• Reactive Oxygen Species (metabolism)