Abstract | OBJECTIVE: METHODS: A total of 96 clomiphene resistance polycystic ovary syndrome patients infertility were randomly divided into an LE group, and HMG group (n = 48). LE group orally received letrozole at 5.0 mg/d on the 3rd-5th days of menstrual cycle for 5 consecutive days, and 75 U/d HMG was given through intramuscular injection for 5 days starting from the third day of menstrual cycle in HMG group. Number of growing and mature follicles, serum E2 (pg/mL), serum P (ng/mL), endometrial thickness, occurrence of pregnancy and miscarriage were observed. RESULTS: There was no significant difference in the number of ovulation cycles between the 2 groups (53.6% vs 64.7%, P > .05). The number of mature follicular cycles in the HMG group was higher than that of the letrozole group (P < .01). There were no significant differences in the clinical pregnancy rate (22.9% vs 27.1%, P > .05) and abortion rate (6.2% vs 10.4%, P > .05). There was no significant difference in the endometrial thickness between the 2 groups on the day of HCG injection [(9.1 ± 0.2) mm vs (10.7 ± 1.6) mm, P > .05]; the serum estradiol (E2) was lower in the letrozole group. The incidence of ovarian cysts was lower than that of HMG group (P < .05). There was2 ovarian hyperstimulation syndrome in the letrozole group; the incidence of ovarian hyperstimulation syndrome in the HMG group was 12.5%. CONCLUSION:
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Authors | Shaoquan Shi, Ting Hong, Fangfang Jiang, Yuan Zhuang, Le Chen, Xiaoling Huang |
Journal | Medicine
(Medicine (Baltimore))
Vol. 99
Issue 4
Pg. e18383
(Jan 2020)
ISSN: 1536-5964 [Electronic] United States |
PMID | 31977842
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Clomiphene
- Estradiol
- Menotropins
- Letrozole
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Topics |
- Abortion, Spontaneous
(epidemiology)
- Adult
- Clomiphene
(pharmacology)
- Endometrium
(drug effects)
- Estradiol
(blood)
- Female
- Humans
- Infertility, Female
(drug therapy)
- Letrozole
(therapeutic use)
- Menotropins
(therapeutic use)
- Ovarian Cysts
(chemically induced)
- Ovarian Hyperstimulation Syndrome
(chemically induced)
- Ovulation
(drug effects)
- Ovulation Induction
(methods)
- Polycystic Ovary Syndrome
(drug therapy)
- Pregnancy
- Young Adult
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