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Clomiphene (Clomifene)

A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.

Also Known As:

Clomifene; Clomid; Clomifen; Enclomifene; Serophene; Zuclomifene; Clomide; Clomiphene Citrate; Clomiphene Hydrochloride; Clostilbegit; Dyneric; En-Clomiphene; Enclomiphen; Enclomiphene Citrate; Gravosan; Klostilbegit; trans-Clomiphene Citrate; Citrate, Clomiphene; Citrate, Enclomiphene; Citrate, trans-Clomiphene; En Clomiphene; Hydrochloride, Clomiphene; trans Clomiphene Citrate; Chloramiphene; Enclomiphene; Zuclomiphene; Ethanamine, 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl-

Networked: 1525 relevant articles (137 outcomes, 193 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Hydrocarbons: 412
  - Cyclic Hydrocarbons: 3
    - Aromatic Hydrocarbons: 132
      - Benzene Derivatives: 13
        Benzylidene Compounds
        Stilbenes: 79
        Clomiphene: 1525
        4-hydroxyclomiphene: 1
        1-(4-(2-(diethylamino)ethoxy)-phenyl)-1-(phenyl)-2-(3-methoxy-4-hydroxyphenyl)-2-chloroethane
        1-(4-fluorophenyl)-1-(4-(2-N,N-diethylamino)ethoxy)phenyl-2-phenylethylene
        1-(p-(beta-diethylaminoethoxy)phenyl)-2-nitro-1,2-diphenylethylene
        1-(phenyl)-1-(4-(2-(diethylamino)-ethoxy)phenyl)-2-(4-hydroxyphenyl)-2-chloroethane
        2-(4-(2-bromo-1,2-diphenylvinyl)phenoxy)triethylamine
        3-methoxy-4-hydroxyclomiphene
        EIPW 113
        MDL 101986
        MDL 103323

Experts

1.	Legro, Richard S: 17 articles (12/2015 - 02/2007)
2.	Abu Hashim, Hatem: 14 articles (09/2015 - 09/2010)
3.	Badawy, Ahmed: 14 articles (07/2014 - 09/2006)
4.	Diamond, Michael P: 12 articles (09/2015 - 02/2007)
5.	Palomba, Stefano: 12 articles (06/2010 - 10/2004)
6.	Coutifaris, Christos: 11 articles (09/2015 - 02/2007)
7.	Falbo, Angela: 11 articles (06/2010 - 10/2004)
8.	Zullo, Fulvio: 11 articles (06/2010 - 10/2004)
9.	Orio, Francesco: 11 articles (06/2010 - 10/2004)
10.	Zhang, Heping: 10 articles (09/2015 - 10/2010)

Related Diseases

1.	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 11/01/1996 - "However, ovarian volume in the Clomiphene Citrate nonresponders was significantly greater than in Clomiphene Citrate responders in the polycystic ovarian syndrome group. " 04/01/2011 - "Ovulation induction with clomiphene citrate and timed intercourse is as effective as that with intrauterine insemination for achieving pregnancy in polycystic ovary syndrome and could represent the initial treatment option, being less invasive and less expensive than intrauterine insemination." 11/01/2004 - "Clomiphene citrate (CC) is widely used as first-line treatment for ovulation induction in anovulatory women with polycystic ovary syndrome (PCOS). " 05/01/2002 - "Gonadotrophin concentrations increase up to days 5-9 when follicles are selected, and clomiphene is effective in patients with polycystic ovary syndrome (PCOS). " 01/01/2001 - "Both rFSH and uFSH are known to be effective in inducing ovulation in women with clomiphene-resistant polycystic ovary syndrome. "
2.	Infertility (Sterility) 01/01/2013 - "Clomiphene citrate (CC) is most commonly used as a first-line treatment of infertility. " 01/01/2000 - "These data suggest statistically and clinically significant improvement in pregnancy rate following clomiphene citrate in women with unexplained infertility. " 04/01/2004 - "Clomiphene citrate combined with IUI is more effective than timed intercourse in the natural cycle at achieving pregnancy in couples with ovulatory infertility. " 04/01/2008 - "The combined treatment of clomiphene citrate, pertubation and insemination can be used as a cost-effective, first-line treatment for couples with unexplained infertility." 08/01/1998 - "Clomiphene citrate + IUI is a cost-effective treatment for unexplained infertility. "
3.	Anovulation 01/01/1990 - "Ovarian stimulation with pure urinary FSH (Fertinorm, Serono Freiburg, FRG) shows therapeutic efficacy in patients with chronic clomiphene-resistant anovulation and elevated androgen levels. " 05/01/1995 - "In conclusion, this study shows that the applied step-down regimen for gonadotrophin induction of ovulation can be a safe and effective treatment alternative for patients with clomiphene-resistant anovulation. " 01/01/2013 - "The M-OVIN study: does switching treatment to FSH and / or IUI lead to higher pregnancy rates in a subset of women with world health organization type II anovulation not conceiving after six ovulatory cycles with clomiphene citrate - a randomised controlled trial." 05/01/2011 - "Chinese herbal medicine and clomiphene citrate for anovulation: a meta-analysis of randomized controlled trials." 08/01/1996 - "Infertile female patients (n = 234) suffering from WHO group II anovulation, and who failed to became pregnant with clomiphene citrate, were included in a multicenter, prospective, clinical study of treatment with a protocol of chronic low-dose and small incremental rises with urinary purified or highly purified FSH. "
4.	Hypogonadism (Hypergonadotropic Hypogonadism) 09/01/2014 - "Clomiphene citrate (CC) is as an effective treatment for men with hypogonadism (HG). " 11/01/2012 - "Clomiphene citrate is safe and effective for long-term management of hypogonadism." 12/01/2006 - "To review the management of male hypogonadotropic hypogonadism (HH) and evaluate the efficacy of clomiphene citrate (CC). " 09/01/2015 - "Clomiphene-Associated Suicide Behavior in a Man Treated for Hypogonadism: Case Report and Review of The Literature." 09/01/2014 - "Enclomiphene citrate reverses the two hallmarks of secondary hypogonadism, namely, low serum total T and low or inappropriately normal LH while preserving sperm production. "
5.	Male Infertility (Male Sterility) 07/01/2013 - "Based on the reviewed studies there is insufficient evidence to indicate that clomiphene is effective for the treatment of male infertility." 08/01/1992 - "This study provides no evidence for the efficacy of clomiphene citrate for the treatment of idiopathic male infertility." 05/01/1988 - "A controlled comparison of the efficacy of clomiphene citrate in male infertility." 07/01/2013 - "A literature search of MEDLINE (1966-June 2012) and EMBASE (1980-June 2012) was conducted using the medical terms clomiphene and male infertility and 9 clinical studies were identified. " 08/01/1992 - "A double-blind trial of clomiphene citrate for the treatment of idiopathic male infertility. "

Related Drugs and Biologics

1.	Metformin (Glucophage)
2.	Clomiphene (Clomifene)
3.	Gonadotropin-Releasing Hormone (GnRH)
4.	Gonadotropins
5.	letrozole (Femara)
6.	Testosterone (Sustanon)
7.	Estrogens (Estrogen)
8.	Bromocriptine (Parlodel)
9.	Estrogen Receptor Modulators (Antiestrogen)
10.	Dexamethasone (Maxidex)

Related Therapies and Procedures

1.	Diathermy
2.	Electrocoagulation (Electrocautery)
3.	Injections
4.	Laser Therapy (Surgery, Laser)
5.	Laparoscopes (Laparoscope)