HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Glucose-Sensing Transcription Factor MondoA/ChREBP as Targets for Type 2 Diabetes: Opportunities and Challenges.

Abstract
The worldwide increase in type 2 diabetes (T2D) is becoming a major health concern, thus searching for novel preventive and therapeutic strategies has become urgent. In last decade, the paralogous transcription factors MondoA and carbohydrate response element-binding protein (ChREBP) have been revealed to be central mediators of glucose sensing in multiple metabolic organs. Under normal nutrient conditions, MondoA/ChREBP plays vital roles in maintaining glucose homeostasis. However, under chronic nutrient overload, the dysregulation of MondoA/ChREBP contributes to metabolic disorders, such as insulin resistance (IR) and T2D. In this review, we aim to provide an overview of recent advances in the understanding of MondoA/ChREBP and its roles in T2D development. Specifically, we will briefly summarize the functional similarities and differences between MondoA and ChREBP. Then, we will update the roles of MondoA/ChREBP in four T2D-associated metabolic organs (i.e., the skeletal muscle, liver, adipose tissue, and pancreas) in physiological and pathological conditions. Finally, we will discuss the opportunities and challenges of MondoA/ChREBP as drug targets for anti-diabetes. By doing so, we highlight the potential use of therapies targeting MondoA/ChREBP to counteract T2D and its complications.
AuthorsZiyi Song, Hao Yang, Lei Zhou, Fajun Yang
JournalInternational journal of molecular sciences (Int J Mol Sci) Vol. 20 Issue 20 (Oct 16 2019) ISSN: 1422-0067 [Electronic] Switzerland
PMID31623194 (Publication Type: Journal Article, Review)
Chemical References
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Biomarkers
  • Insulin
  • MLXIP protein, human
  • MLXIPL protein, human
  • Glucose
Topics
  • Adipose Tissue (drug effects, metabolism)
  • Animals
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors (genetics, metabolism)
  • Biomarkers
  • Diabetes Mellitus, Type 2 (drug therapy, etiology, metabolism)
  • Gene Expression Regulation
  • Glucose (metabolism)
  • Humans
  • Insulin (metabolism)
  • Insulin Resistance
  • Liver (metabolism)
  • Pancreas (metabolism)
  • Signal Transduction

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: