Abstract | BACKGROUND AND AIM: Cirrhotic patients with gastroesophageal varices and non-tumoral portal vein thrombosis have a higher risk of re- bleeding and poor prognosis. This study aimed to analyze inflammatory biomarkers and thromboelastography in cirrhotic patients with portal vein thrombosis. METHODS: A total of 385 consecutive cirrhotic patients with gastroesophageal varices were prospectively enrolled between 1 December 2016, and 31 August 2017. Of these, 231 were eligible for analysis and were divided into portal vein thrombosis (n = 103) and non-portal vein thrombosis (n = 128) groups based on computerized tomography angiography findings. RESULTS: Patients with portal vein thrombosis generally had higher Child-Pugh scores than those without portal vein thrombosis (6.38 ± 0.12 vs. 5.81 ± 0.09, P < 0.001). The serum albumin levels were significantly lower in patients with portal vein thrombosis (35.90 ± 0.52 vs. 38.52 ± 0.43, P < 0.001). The portal vein thrombosis group had significant higher serum levels of interleukin 6 [4.85 (3.15-6.99) vs. 3.09 (2.06-5.20) pg/ml, P < 0.001] and tumor necrosis factor alpha [10.70 (7.60-15.20) vs. 9.07 (7.03-11.60) pg/ml, P = 0.020]. The interleukin 6 level was 2.5-fold higher in patients with portal vein thrombosis (adjusted odds ratio: 2.574; 95% confidential interval: 1.248-5.310). Thromboelastography showed that TEG-R, the reaction time, was significantly lower in the portal vein thrombosis group [5.20 (4.80-6.30) vs. 6.00 (5.20-6.95), P = 0.009], indicating enhanced coagulation activity. CONCLUSION:
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Authors | Xiaoquan Huang, Xiaowen Fan, Rui Zhang, Siyu Jiang, Kaiqi Yang, Shiyao Chen |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 32
Issue 3
Pg. 401-405
(03 2020)
ISSN: 1473-5687 [Electronic] England |
PMID | 31356372
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Esophageal and Gastric Varices
(diagnosis, etiology)
- Humans
- Inflammation
(pathology)
- Liver Cirrhosis
(complications, pathology)
- Portal Vein
(diagnostic imaging, pathology)
- Varicose Veins
(pathology)
- Venous Thrombosis
(diagnostic imaging, etiology, pathology)
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