Protective effect of sakuranetin in brain cells of dementia model rats.

Abstract

Alzheimer's disease (AD) is a high-incidence neurodegenerative disease with complex and diverse pathogenesis. With aging of the population and continuous improvement of living standards, the incidence of AD is on the increase. Therefore, there is need to develop more effective AD drugs in order to improve the quality of life of the elderly. Sakuranetin (SAK) is a dihydroflavonoid compound extracted from plants. It has many physiological properties. In this study, the effect of SAK on spatial discrimination in a rat model of cognitive dysfunction exposed to D-galactose was investigated with respect to its effect on malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels, and on the expressions of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and nuclear factor-κB inhibitory factor-α (IκBα) in hippocampus of rats. The results obtained suggest that SAK may exert protective effects on brain cells through anti-oxidation mechanism. Moreover, the improvement in learning and memory impairment by SAK may also be related to the inhibition of inflammatory mediators in brain tissue. These findings provide scientific evidence that can be exploited for more effective treatment of Alzheimer's disease.

• Authors: Chen Li, Chunting Hu, Ruili Wang, Hui Wang, Qiaoya Ma, Songsheng Chen, Ya He
• Journal: Cellular and molecular biology (Noisy-le-Grand, France) (Cell Mol Biol (Noisy-le-grand)) Vol. 65 Issue 5 Pg. 54-58 (Jun 30 2019) ISSN: 1165-158X [Electronic] France
• PMID: 31304907 (Publication Type: Journal Article)

Chemical References

• Flavonoids
• Il6 protein, rat
• Interleukin-6
• Plant Extracts
• Protective Agents
• Tumor Necrosis Factor-alpha
• NF-KappaB Inhibitor alpha
• sakuranetin
• Malondialdehyde
• Glutathione Peroxidase
• Superoxide Dismutase
• Galactose

Topics

• Alzheimer Disease (drug therapy)
• Animals
• Behavior, Animal (drug effects)
• Cognitive Dysfunction (chemically induced)
• Disease Models, Animal
• Flavonoids (administration & dosage, pharmacology)
• Galactose (pharmacology)
• Glutathione Peroxidase (metabolism)
• Hippocampus (drug effects, metabolism)
• Interleukin-6 (metabolism)
• Male
• Malondialdehyde (metabolism)
• Memory (drug effects)
• NF-KappaB Inhibitor alpha (metabolism)
• Oryza (chemistry)
• Plant Extracts (administration & dosage, pharmacology)
• Protective Agents (administration & dosage, pharmacology)
• Rats
• Rats, Wistar
• Signal Transduction (drug effects)
• Spatial Navigation (drug effects)
• Superoxide Dismutase (metabolism)
• Tumor Necrosis Factor-alpha (metabolism)