Association of Serum Retinol-Binding Protein 4 Levels and the Risk of Incident Type 2 Diabetes in Subjects With Prediabetes.

Abstract

OBJECTIVE:

To explore the association of serum retinol-binding protein 4 (RBP4) levels and risk for the development of type 2 diabetes in individuals with prediabetes.

RESEARCH DESIGN AND METHODS:

A population-based prospective study was conducted among 1,011 Chinese participants with prediabetes (average age 55.6 ± 7.2 years). Incident type 2 diabetes was diagnosed according to the American Diabetes Association 2010 criteria. Serum RBP4 levels were measured using a commercially available ELISA. We analyzed the association of serum RBP4 levels with the risk of incident type 2 diabetes using the Cox proportional hazards model.

RESULTS:

During a median follow-up period of 3.1 years, 153 participants developed incident type 2 diabetes. A U-shaped association was observed between serum RBP4 levels and the risk of incident type 2 diabetes, with the lowest risk in the RBP4 range of 31-55 μg/mL. Multivariate Cox regression model analysis showed that serum RBP4 levels <31 μg/mL and RBP4 levels >55 μg/mL were associated with an increased risk of incident type 2 diabetes. The adjusted hazard ratios (95% CI) were 2.01 (1.31-3.09) and 1.97 (1.32-2.93), respectively, after adjusting for age, sex, BMI, waist circumference, γ-glutamyltransferase, HOMA of insulin resistance index, fasting plasma glucose, 2-h plasma glucose, and glycated hemoglobin (HbA1c) levels.

CONCLUSIONS:

A U-shaped relationship exists between serum RBP4 levels and the risk of incident type 2 diabetes in subjects with prediabetes.

• Authors: Jiahua Fan, Songping Yin, Diaozhu Lin, Yangqing Liu, Nixuan Chen, Xinxiu Bai, Qiuyi Ke, Jia Shen, Lili You, Xiuhong Lin, Feng Li, Fengyi He, Li Yan, Chaogang Chen, Min Xia
• Journal: Diabetes care (Diabetes Care) Vol. 42 Issue 8 Pg. 1574-1581 (08 2019) ISSN: 1935-5548 [Electronic] United States
• PMID: 31186297 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 by the American Diabetes Association.

Chemical References

• Biomarkers
• Glycated Hemoglobin A
• Insulin
• RBP4 protein, human
• Retinol-Binding Proteins, Plasma

Topics

• Adult
• Biomarkers (blood)
• China (epidemiology)
• Diabetes Mellitus, Type 2 (blood, diagnosis, epidemiology)
• Disease Progression
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Incidence
• Insulin (blood)
• Insulin Resistance (physiology)
• Male
• Middle Aged
• Prediabetic State (blood, diagnosis, epidemiology, pathology)
• Prospective Studies
• Retinol-Binding Proteins, Plasma (analysis, metabolism)
• Risk Factors