Modulation of miR-34a in curcumin-induced antiproliferation of prostate cancer cells.

Abstract

Curcumin is a phytochemical which exhibits significant inhibitory effect in multiple cancers including prostate cancer. MicroRNA-34a (miR-34a) was found to be a master tumor suppressor miRNA and regulated the growth of cancer cells. To date, however, the role of miR-34a in the anticancer action of curcumin against prostate cancer has been rarely reported. In the present study, we showed that curcumin altered the expression of cell cycle-related genes (cyclin D1, PCNA, and p21) and inhibited the proliferation of prostate cancer cells. Furthermore, we found that curcumin significantly upregulated the expression of miR-34a, along with the downregulated expression of β-catenin and c-myc in three prostate cancer cell lines. Inhibition of miR-34a activated β-catenin/c-myc axis, altered cell cycle-related genes expression and significantly suppressed the antiproliferation effect of curcumin in prostate cancer cells. Findings from this study revealed that miR-34a plays an important role in the antiproliferation effect of curcumin in prostate cancer.

• Authors: Mingming Zhu, Zongmei Zheng, Jiaming Huang, Xiao Ma, Cong Huang, Rui Wu, Xiaoting Li, Zhaofeng Liang, Feifei Deng, Jieshu Wu, Shanshan Geng, Chunfeng Xie, Caiyun Zhong
• Journal: Journal of cellular biochemistry (J Cell Biochem) Vol. 120 Issue 9 Pg. 15616-15624 (09 2019) ISSN: 1097-4644 [Electronic] United States
• PMID: 31042325 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 Wiley Periodicals, Inc.

Chemical References

• MIRN34 microRNA, human
• MicroRNAs
• Curcumin

Topics

• Animals
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Curcumin (pharmacology)
• Gene Expression Regulation, Neoplastic (drug effects)
• Humans
• Male
• Mice
• MicroRNAs (genetics)
• Prostate (drug effects, pathology)
• Prostatic Neoplasms (drug therapy, genetics, pathology)
• Xenograft Model Antitumor Assays