Abstract | BACKGROUND/AIMS: METHODS: We measured sclerostin, osteoprotegerin, and B-ALP in fasting and oral glucose tolerance test (oGTT) serum samples from 1,325 children and adolescents, and during 24-h profiles and after exercise and glucose exposure in young adults. RESULTS: In addition to the positive relationship with height standard deviation scores (SDS), sclerostin (r = 0.035, p < 0.001) and B-ALP (r = 0.06, p = 0.028) increased, whereas osteoprotegerin (r = -0.098, p < 0.001) decreased with BMI SDS. Furthermore, B-ALP correlated with fasting- and oGTT-derived markers of glucose and insulin metabolism suggestive of insulin resistance. To evaluate potential confounding diurnal variation of bone markers, we performed 24-h profiles. B-ALP and osteoprotegerin had lower night-time levels. Exercise acutely and transiently increased B-ALP and osteoprotegerin levels, but glucose ingestion had no effect. CONCLUSIONS:
|
Authors | Juraj Stanik, Jürgen Kratzsch, Kathrin Landgraf, Mandy Vogel, Joachim Thiery, Wieland Kiess, Antje Körner |
Journal | Hormone research in paediatrics
(Horm Res Paediatr)
Vol. 91
Issue 1
Pg. 1-8
( 2019)
ISSN: 1663-2826 [Electronic] Switzerland |
PMID | 30904905
(Publication Type: Journal Article)
|
Copyright | © 2019 S. Karger AG, Basel. |
Chemical References |
- Adaptor Proteins, Signal Transducing
- Biomarkers
- Bone Morphogenetic Proteins
- Genetic Markers
- Osteoprotegerin
- SOST protein, human
- TNFRSF11B protein, human
- Alkaline Phosphatase
|
Topics |
- Adaptor Proteins, Signal Transducing
- Adolescent
- Adolescent Development
- Alkaline Phosphatase
(blood)
- Biomarkers
(blood)
- Bone Morphogenetic Proteins
(blood)
- Child
- Child Development
- Child, Preschool
- Female
- Genetic Markers
- Humans
- Infant
- Insulin Resistance
- Male
- Obesity
(blood)
- Osteoprotegerin
(blood)
|