[Clinical Observation of Chaihu Guizhi Decoction in Treating SAPHO Syndrome].

Abstract

Objective To evaluate the clinical efficacy and safety of Modified Chaihu Guizhi De- coction on SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome. Methods Totally 40 patients with SAPHO syndrome were randomized to the treatment group(20 cases) and control group(20 cases). The treatment group was treated with Modified Chaihu Guizhi Decoction, and the control group with alendronate sodium 70 mg each week. The therapeutic course for all was 12 weeks. The Visual Analogue Scale (VAS) pain scores, bath ankylosing spondylitis activity index (BASDAI) , bath ankylosing spondylitis functional index(BASFI) , erythrocyte sedimentation rate(ESR) and hypersensitivity C reactive protein (hs-CRP) were measured before and after treatment. Adverse events were observed. Results The VAS, BASDAI, and BASFI score significantly improved compared with baseline in the treatment group (P <0. 01 , P <0. 05). The VAS and BASDAI score of the treatment group improved compared with the control group after treatment (P <0. 05). Three patients in the control group reported adverse events with digestive tract symptoms, while there was no obvious adverse drug reactions in the treatment group. Conclusions Modified Chaihu Guizhi Decoction was superior to alendronate sodium in the treat- ment of SAPHO syndrome without obvious adverse drug reactions.

• Authors: Chen Li, Jin-He Liu, Wei-Xin Hao, Wen Zhang, Zhen-Hua Dong
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 37 Issue 4 Pg. 429-432 (04 2017) ISSN: 1003-5370 [Print] China
• PMID: 30650500 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Drugs, Chinese Herbal
• guizhi decoction

Topics

• Acquired Hyperostosis Syndrome (drug therapy)
• Blood Sedimentation
• Drugs, Chinese Herbal (therapeutic use)
• Humans
• Severity of Illness Index
• Spondylitis, Ankylosing