Resveratrol Protects Against Renal Damage via Attenuation of Inflammation and Oxidative Stress in High-Fat-Diet-Induced Obese Mice.

Abstract

Oxidative stress and inflammation play an important role in the chronic kidney disease associated with obesity. Resveratrol (RSV) has been reported to exhibit a wide range of biological activities including antioxidant and anti-inflammatory properties. The objective of the present study was to investigate the effects of RSV on renal inflammation and oxidative stress in obese mice induced by high-fat diet. Male C57BL/6 mice were induced to have nephropathy associated obesity by high-fat diet for 12 weeks. After 8 weeks of feeding, oral supplementation with 100 mg RSV/kg body weight/day was applied with the high-fat-diet feeding for another 4 weeks. The results showed that RSV treatment protected against renal damage induced by high-fat diet, as evidenced by the decreased serum creatinine and urea nitrogen levels, alleviation of glomerular damage, and tubular vacuolization. In addition, RSV enhanced the antioxidant enzyme activity; improved the expression of genes related to inflammation; and decreased the malondialdehyde, tumor necrosis factor-α, and interleukin-6 concentrations in the kidney of high-fat-diet mice. In conclusion, RSV could alleviate renal damage in obese mice induced by high-fat diet via suppressing inflammation and oxidative stress.

• Authors: Kang Cheng, Zhihua Song, Yanan Chen, Simian Li, Yuying Zhang, Hao Zhang, Lili Zhang, Chao Wang, Tian Wang
• Journal: Inflammation (Inflammation) Vol. 42 Issue 3 Pg. 937-945 (Jun 2019) ISSN: 1573-2576 [Electronic] United States
• PMID: 30554371 (Publication Type: Journal Article)

Chemical References

• Resveratrol

Topics

• Animals
• Diet, High-Fat (adverse effects)
• Inflammation (prevention & control)
• Kidney (injuries)
• Kidney Diseases (drug therapy, prevention & control)
• Mice
• Mice, Obese
• Oxidative Stress (drug effects)
• Resveratrol (pharmacology, therapeutic use)