Abstract | BACKGROUND: METHODS: Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE. Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites. RESULTS: At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all comparisons of abaloparatide to placebo and to teriparatide). Findings were similar for the >0% and >6% responder thresholds. CONCLUSIONS: In postmenopausal women with osteoporosis, a significantly greater proportion of patients treated with abaloparatide experienced increases in BMD than did those treated with placebo or teriparatide.
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Authors | P D Miller, G Hattersley, E Lau, L A Fitzpatrick, A G Harris, G C Williams, M-Y Hu, B J Riis, L Russo, C Christiansen |
Journal | Bone
(Bone)
Vol. 120
Pg. 137-140
(03 2019)
ISSN: 1873-2763 [Electronic] United States |
PMID | 30359763
(Publication Type: Clinical Trial, Phase III, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Parathyroid Hormone-Related Protein
- Placebos
- Teriparatide
- abaloparatide
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Topics |
- Aged
- Bone Density
(drug effects)
- Bone and Bones
(drug effects)
- Female
- Humans
- Parathyroid Hormone-Related Protein
(pharmacology)
- Placebos
- Teriparatide
(pharmacology)
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