Recent trends in click chemistry as a promising technology for virus-related research.

Abstract

Click chemistry involves reactions that were originally introduced and used in organic chemistry to generate substances by joining small units together with heteroatom linkages (C-X-C). Over the last few decades, click chemistry has been widely used in virus-related research. Using click chemistry, the virus particle as well as viral protein and nucleic acids can be labeled. Subsequently, the labeled virions or molecules can be tracked in real time. Here, we reviewed the recent applications of click reactions in virus-related research, including viral tracking, the design of antiviral agents, the diagnosis of viral infection, and virus-based delivery systems. This review provides an overview of the general principles and applications of click chemistry in virus-related research.

• Authors: Ting Ouyang, Xiaohui Liu, Hongsheng Ouyang, Linzhu Ren
• Journal: Virus research (Virus Res) Vol. 256 Pg. 21-28 (09 02 2018) ISSN: 1872-7492 [Electronic] Netherlands
• PMID: 30081058 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Antiviral Agents

Topics

• Antiviral Agents (isolation & purification)
• Click Chemistry (trends)
• Drug Discovery (methods, trends)
• Staining and Labeling (methods)
• Virology (methods, trends)
• Viruses (growth & development, isolation & purification)