Abstract | BACKGROUND:
Therapy with local anesthetics (LAs), also known as neural therapy, is used in integrative medicine because of its anti-inflammatory properties. Ester-linked LAs are often avoided because of their alleged high allergenicity. Little data supports this assumption and hence the importance of our investigation on type-1 allergies against ester- and amide-linked LAs. We performed a prospective, double-blinded, placebo-controlled observational study. METHODS: RESULTS: No type-1 allergy was observed. The mean erythema diameter of the wheals after 10 minutes was procaine 8.0 ± 6.4 mm, mepivacaine 7.6 ± 6.3 mm, lidocaine 4.4 ± 4.8 mm, and NaCl 3.7 ± 3.2 mm. The wheal diameter of all substances showed a crescendo-decrescendo phenomenon. The procaine and mepivacaine wheals were significantly larger than those of lidocaine and NaCl. No general signs of hypersensitivity were observed. Diameter and intensity were independent of the injection site, order of injection, age, gender, and body mass index. CONCLUSION:
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Authors | Stefan Weinschenk, Caroline Mergenthaler, Christina Armstrong, Richard Göllner, Markus W Hollmann, Thomas Strowitzki |
Journal | BioMed research international
(Biomed Res Int)
Vol. 2017
Pg. 9804693
( 2017)
ISSN: 2314-6141 [Electronic] United States |
PMID | 30035116
(Publication Type: Journal Article)
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