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Mepivacaine (Carbocaine)

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A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)

Also Known As:

Carbocaine; Scandonest; 3M Brand of Mepivacaine Hydrochloride; Abbott Brand of Mepivacaine Hydrochloride; Astra Brand of Mepivacaine Hydrochloride; AstraZeneca Brand of Mepivacaine Hydrochloride; Aventis Brand of Mepivacaine Hydrochloride; Braun Brand of Mepivicaine Hydrochloride; Carbocaïne; Clarben Brand of Mepivacaine Hydrochloride; Dentsply Brand of Mepivacaine Hydrochloride; Hexal Brand of Mepivacaine Hydrochloride; Inibsa Brand of Mepivacaine Hydrochloride; Isocaine; Isogaine; Meaverin; Mecain; Mepihexal; Mepivacain-Injektopas; Mepivacaina Braun; Mepivacaine Hydrochloride; Mepivacaine Monohydrochloride; Mepivastesin; Novocol Brand of Mepivacaine Hydrochloride; Pascoe Brand of Mepivacaine Hydrochloride; Polocaine; Sanofi Brand of Mepivacaine Hydrochloride; Scandicain; Scandicaine; Scandinibsa; curasan Brand of Mepivacaine Hydrochloride; Braun, Mepivacaina; Hydrochloride, Mepivacaine; Mepivacain Injektopas; Monohydrochloride, Mepivacaine; 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-

Networked: 265 relevant articles (16 outcomes, 26 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Piperidines: 12
    - Mepivacaine: 265
      - dexivacain

Experts

1.	Casati, A: 5 articles (09/2008 - 02/2000)
2.	Fanelli, G: 4 articles (09/2008 - 02/2000)
3.	Crincoli, Vito: 2 articles (01/2015 - 01/2009)
4.	Brienza, Nicola: 2 articles (01/2015 - 01/2009)
5.	Favia, Gianfranco: 2 articles (01/2015 - 01/2009)
6.	Reader, Al: 2 articles (09/2014 - 02/2004)
7.	Nusstein, John: 2 articles (09/2014 - 02/2004)
8.	Beck, Mike: 2 articles (09/2014 - 02/2004)
9.	Gomar, C: 2 articles (12/2012 - 02/2001)
10.	Ranali, José: 2 articles (03/2011 - 02/2010)

Related Diseases

1.	Pain (Aches) 09/01/2014 - "In theory, using 3% mepivacaine initially for an inferior alveolar nerve (IAN) block would decrease the pain of injection, provide faster onset, and increase anesthetic success. " 01/01/2011 - "Mepivacaine, an amide-type local anesthetic, has been used to relieve local pain. " 01/01/2009 - "It presents better pain relief when compared to mepivacaine in the immediate postoperative period as evidenced by lower VAS scores." 01/01/2009 - "Timing of pain appearance and of first drug consumption was significantly lower in the mepivacaine group (P < .05). " 02/01/2006 - "The use of bilateral periprosthetic block with mepivacaine is a very effective and useful technique, well tolerated by the patient, which almost completely abolishes the pain and discomfort associated with the prostate biopsy procedure. "
2.	Postoperative Pain 12/10/2002 - "DEX is not superior to mepivacaine in reducing the discomfort of the procedure but does significantly reduce postoperative pain." 06/01/1997 - "The three groups did not differ in terms of patient demographics, the duration of anesthesia, the amount of epidural mepivacaine administered, or the postoperative pain rating. " 01/01/2006 - "No difference was seen between the mepivacaine and control groups regarding postoperative pain as estimated using either the VAS or the Wong-Baker FACES pain rating scale. " 01/01/2009 - "Postoperative pain relief after surgical removal of impacted third molars: a single-blind, randomized, controlled study to compare levobupivacaine and mepivacaine." 01/01/2015 - "The Effectiveness of Ropivacaine and Mepivacaine in the Postoperative Pain after Third Lower Molar Surgery."
3.	Edema 12/01/2008 - "Mepivacaine effectively eliminated lameness within 45 minutes after injection, regardless of whether TA was also administered, whereas TA reduced lameness, edema, and concentration of synovial fluid protein after the second LPS injection, regardless of whether mepivacaine was also injected. " 09/01/2009 - "Both lidocaine and mepivacaine attenuate the increase of pulmonary arterial pressure (PAP) and lung edema development. " 11/01/1999 - "Facial edema, oral ulcers, and a cutaneous eruption following a dental procedure utilizing diflunisal and mepivacaine." 09/01/2009 - "Lidocaine and mepivacaine are more effective in reducing PAP and edema formation, but long-acting local anesthetics also inhibit ET-1 depletion and therefore have increased anti-inflammatory properties." 01/01/1988 - "Nerve fiber injury and endoneurial edema were induced by the injection of the local anesthetic 2-chloroprocaine, tetracaine, procaine, etidocaine or mepivacaine into the soft tissue and fascia surrounding the sciatic nerve of Sprague-Dawley rats. "
4.	Wounds and Injuries (Trauma) 08/01/2001 - "Twenty ml of 1% mepivacaine was injected around the wound at the completion of surgery. " 07/01/2010 - "The objective of this study is to determine whether the postoperative wound infiltration with a mixture of bupivacaine, mepivacaine and adrenaline is more effective than the sole application of bupivacaine. "
5.	Pulpitis 12/01/1997 - "To determine the efficacy of a supplemental intraosseous injection of 3% mepivacaine in mandibular posterior teeth with irreversible pulpitis. " 12/01/1997 - "Anesthetic efficacy of the supplemental intraosseous injection of 3% mepivacaine in irreversible pulpitis." 12/01/1997 - "For mandibular posterior teeth with irreversible pulpitis, a supplemental intraosseous injection of 3% mepivacaine increased anesthetic success. " 11/01/2013 - "To evaluate the effect of preoperative oral ibuprofen (IBU) on the success of inferior alveolar nerve blocks (IANBs) with mepivacaine containing 1 : 100 000 epinephrine for patients with symptomatic irreversible pulpitis (SIP). " 02/01/2007 - "A double-blind comparison of a supplemental interligamentary injection of fentanyl and mepivacaine with 1:200,000 epinephrine for irreversible pulpitis."

Related Drugs and Biologics

1.	Epinephrine (Adrenaline)
2.	Lidocaine (Xylocaine)
3.	Bupivacaine (Bupivacaine Hydrochloride)
4.	Local Anesthetics
5.	EMLA
6.	Carticaine (Articaine)
7.	levobupivacaine (Chirocaine)
8.	ropivacaine (Naropin)
9.	Buprenorphine (Subutex)
10.	2-(4-toluidino)-6-naphthalenesulfonic acid (TNS)

Related Therapies and Procedures

1.	Spinal Anesthesia
2.	Anesthesia
3.	Epidural Anesthesia
4.	Tourniquets
5.	General Anesthesia