High Levels of Serum Uric Acid, Cystain C and Lipids Concentration and their Clinical Significance in Primary Gouty Arthritis Patients.
Abstract | OBJECTIVE: To investigate the changes of serum Uric Acid (sUA), lipids and Cystatin C (CysC) in primary gout patients, and to explore the clinical significance in gout patients. METHODS: sUA, CysC, high-sensitivity C-reactive Protein ( hsCRP) and other biochemical parameters were measured in 326 gout patient and 210 healthy control subjects, blood cell counts were also detected. Clinical data were collected from gout patients. RESULTS: sUA, CysC, hsCRP, Body Mass Index (BMI), White Blood Cell (WBC) counts, neutrophil Granulocyte (GR), Monocyte (Mo), Triglycerides (TG), plasma Total Cholesterol (TC), Very Low Density Lipoprotein (VLDL), apolipoprotein B100 (apoB100), Blood Glucose (GLU), serum Creatinine (sCr) and Urea Nitrogen (BUN) were significantly increased in gout patients compared with HC subjects (P<0.01, respectively), while lymphocyte counts and High Density Lipoprotein- Cholesterol (HDL-C) were significantly decreased in gout patients compared with HC subjects (P<0.01, respectively). Positive correlations were observed between concentration of sUA and age, TG, VLDL, sCr and CysC (P<0.05, respectively). While negative correlations were observed between the concentration of sUA and HDL-C(P<0.01). Besides, Positive correlations were observed between concentration of CysC and WBC, GR, Mo, apoA1, GLU, sCr, BUN, sUA, hsCRP (P<0.05, respectively). While negative correlations were observed between the concentration of CysC and TC, LDL-C(P<0.01, respectively). CONCLUSIONS:
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Authors | Quan-Bo Zhang, Dan Zhu, Zhong Wen, Ting Yi, Qing Li, Yu-Feng Qing, Jing-Guo Zhou |
Journal | Current rheumatology reviews
(Curr Rheumatol Rev)
Vol. 15
Issue 2
Pg. 141-145
( 2019)
ISSN: 1875-6360 [Electronic] United Arab Emirates |
PMID | 29984668
(Publication Type: Journal Article)
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Copyright | Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. |
Chemical References |
- Biomarkers
- CST3 protein, human
- Cystatin C
- Lipids
- Uric Acid
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Topics |
- Adult
- Aged
- Arthritis, Gouty
(blood)
- Biomarkers
(blood)
- Cystatin C
(blood)
- Female
- Humans
- Lipids
(blood)
- Male
- Middle Aged
- Uric Acid
(blood)
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