Aortic plaque-targeted andrographolide delivery with oxidation-sensitive micelle effectively treats atherosclerosis via simultaneous ROS capture and anti-inflammation.

Abstract

Inflammation and oxidative stress are two major factors that are involved in the pathogenesis of atherosclerosis. A smart drug delivery system that responds to the oxidative microenvironment of atherosclerotic plaques was constructed in the present study. Andrographolide-loaded micelle was assembled from the block copolymer of poly(ethylene glycol) and poly(propylene sulphide) (PEG-PPS) for the purpose of simultaneously decreasing inflammatory response and the level of reactive oxygen species (ROS) to treat atherosclerosis. Owing to the ROS-responsive nature of PEG-PPS, the micelle not only serves as a stimuli-responsive drug carrier to quickly release the encapsulated drug, andrographolide, but also consumes ROS by itself at the pathologic sites, upon which the expressions of pro-inflammatory cytokines are effectively suppressed and oxidative stress is alleviated. Consequently, the andrographolide-loaded micelle demonstrated remarkable therapeutic effects both in vitro and in vivo. In conclusion, the andrographolide-loaded PEG-PPS micelle can synchronically alleviate inflammation and oxidative stress, providing a promising and innovative strategy against atherosclerosis.

• Authors: Teng Wu, Xiaoyan Chen, Yong Wang, Hong Xiao, Yuan Peng, Liteng Lin, Wenhao Xia, Ming Long, Jun Tao, Xintao Shuai
• Journal: Nanomedicine : nanotechnology, biology, and medicine (Nanomedicine) Vol. 14 Issue 7 Pg. 2215-2226 (10 2018) ISSN: 1549-9642 [Electronic] United States
• PMID: 29964220 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2018 Elsevier Inc. All rights reserved.

Chemical References

• Diterpenes
• Drug Carriers
• Micelles
• Polymers
• Reactive Oxygen Species
• Polyethylene Glycols
• andrographolide

Topics

• Animals
• Aorta (pathology)
• Atherosclerosis (drug therapy, metabolism, pathology)
• Diterpenes (administration & dosage, chemistry, pharmacology)
• Drug Carriers (chemistry)
• Drug Delivery Systems
• Female
• Inflammation (drug therapy, metabolism, pathology)
• Male
• Mice, Knockout, ApoE
• Micelles
• Oxidation-Reduction
• Oxidative Stress (drug effects)
• Plaque, Atherosclerotic (drug therapy, metabolism, pathology)
• Polyethylene Glycols (chemistry)
• Polymers (administration & dosage, chemistry)
• Reactive Oxygen Species (metabolism)