Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community-Based Cohort.

Abstract

BACKGROUND:

Adipokines mediate cardiometabolic risk associated with obesity but their role in the pathogenesis of obesity-associated heart failure remains uncertain. We investigated the associations between circulating adipokine concentrations and echocardiographic measures in a community-based sample.

METHODS AND RESULTS:

We evaluated 3514 Framingham Heart Study participants (mean age 40 years, 53.8% women) who underwent routine echocardiography and had select circulating adipokines measured, ie, leptin, soluble leptin receptor, fatty acid-binding protein 4, retinol-binding protein 4, fetuin-A, and adiponectin. We used multivariable linear regression, adjusting for known correlates (including weight), to relate adipokine concentrations (independent variables) to the following echocardiographic measures (dependent variables): left ventricular mass index, left atrial diameter in end systole, fractional shortening, and E/e'. In multivariable-adjusted analysis, left ventricular mass index was inversely related to circulating leptin and fatty acid-binding protein 4 concentrations but positively related to retinol-binding protein 4 and leptin receptor levels (P≤0.002 for all). Left atrial end-systolic dimension was inversely related to leptin but positively related to retinol-binding protein 4 concentrations (P≤0.0001). E/e' was inversely related to leptin receptor levels (P=0.0002). We observed effect modification by body weight for select associations (leptin receptor and fatty acid-binding protein 4 with left ventricular mass index, and leptin with left atrial diameter in end systole; P<0.05 for interactions). Fractional shortening was not associated with any of the adipokines. No echocardiographic trait was associated with fetuin-A or adiponectin concentrations.

CONCLUSIONS:

In our cross-sectional study of a large, young to middle-aged, relatively healthy community-based sample, key indices of subclinical cardiac remodeling were associated with higher or lower circulating concentrations of prohypertrophic and antihypertrophic adipokines in a context-specific manner. These observations may offer insights into the pathogenesis of the cardiomyopathy of obesity.

• Authors: Beatrice von Jeinsen, Meghan I Short, Vanessa Xanthakis, Herman Carneiro, Susan Cheng, Gary F Mitchell, Ramachandran S Vasan
• Journal: Journal of the American Heart Association (J Am Heart Assoc) Vol. 7 Issue 13 (06 21 2018) ISSN: 2047-9980 [Electronic] England
• PMID: 29929991 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

Chemical References

• Adipokines
• Biomarkers

Topics

• Adipokines (blood)
• Adipose Tissue (metabolism, physiopathology)
• Adiposity
• Adult
• Asymptomatic Diseases
• Biomarkers (blood)
• Cardiomegaly (blood, diagnostic imaging, physiopathology)
• Cross-Sectional Studies
• Echocardiography, Doppler
• Female
• Heart (diagnostic imaging, physiopathology)
• Humans
• Male
• Middle Aged
• Predictive Value of Tests
• Ventricular Remodeling