Abstract | INTRODUCTION: OBJECTIVE: To investigate the efficacy of anti- NGF antibody therapy on osteoporotic pain in an OVX-induced mouse model. METHODS:
Ovariectomy- and sham-operated mice were injected with an anti- NGF antibody (10 mg/kg, intraperitoneally, administered 2×, 14 days apart), and the effect on behavioural indices of osteoporosis-related pain and on sensory neuron plasticity was evaluated. RESULTS: Treatment with anti- NGF antibodies attenuated OVX-induced hypersensitivity to mechanical, cold, and heat stimuli on the plantar surface of the hind paw. The OVX-induced impairment in grip force strength, used here as a measure of axial discomfort, was partially reversed by anti- NGF therapy. No changes were observed in the rotarod or open-field tests for overall motor function and activity. Finally, anti- NGF treatment attenuated the increase in calcitonin gene-related peptide-immunoreactive dorsal root ganglia neurons observed in OVX mice. CONCLUSION:
|
Authors | Miyako Suzuki, Magali Millecamps, Seiji Ohtori, Chisato Mori, Laura S Stone |
Journal | Pain reports
(Pain Rep)
Vol. 3
Issue 3
Pg. e652
(May 2018)
ISSN: 2471-2531 [Electronic] United States |
PMID | 29922744
(Publication Type: Journal Article)
|